Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CG14476 - CG14476 gene product from transcript...

Drosophila melanogaster

Synonyms: BcDNA:GH04962, Dmel\CG14476, clot#312

Ziak, M. et al., Zuber, C. et al.

Ziak, Meier, Etter, Roth,

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High impact information on CG14476

With the use of quantitative immunogold electron microscopy, we established the subcellular distribution of GT in rat liver and pancreas and Drosophila melanogaster salivary gland as well as cell lines and correlated it with that of glucosidase II, calreticulin, and pre-Golgi intermediate markers [1].
Two isoforms of trimming glucosidase II exist in mammalian tissues and cell lines but not in yeast and insect cells [2].
DNA-sequencing of different clones demonstrated the existence of two isoforms of glucosidase II which differed by 66 nucleotides due to alternative splicing [2].
We previously cloned glucosidase II and provided in vivo evidence for its involvement in protein folding quality control [2].

References

Immunolocalization of UDP-glucose:glycoprotein glucosyltransferase indicates involvement of pre-Golgi intermediates in protein quality control. Zuber, C., Fan, J.Y., Guhl, B., Parodi, A., Fessler, J.H., Parker, C., Roth, J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Two isoforms of trimming glucosidase II exist in mammalian tissues and cell lines but not in yeast and insect cells. Ziak, M., Meier, M., Etter, K.S., Roth, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

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