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Gene Review

Nox4  -  NADPH oxidase 4

Mus musculus

Synonyms: AI648021, KOX-1, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase, ...
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High impact information on Nox4


Anatomical context of Nox4


Associations of Nox4 with chemical compounds

  • These data suggest a differential response of the cardiac Nox isoforms, gp91phox and Nox4, to Ang II versus pressure overload [4].

Regulatory relationships of Nox4


Analytical, diagnostic and therapeutic context of Nox4


  1. A new superoxide-generating oxidase in murine osteoclasts. Yang, S., Madyastha, P., Bingel, S., Ries, W., Key, L. J. Biol. Chem. (2001) [Pubmed]
  2. The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle. Ellmark, S.H., Dusting, G.J., Fui, M.N., Guzzo-Pernell, N., Drummond, G.R. Cardiovasc. Res. (2005) [Pubmed]
  3. Expression of Nox4 in osteoclasts. Yang, S., Zhang, Y., Ries, W., Key, L. J. Cell. Biochem. (2004) [Pubmed]
  4. Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy. Byrne, J.A., Grieve, D.J., Bendall, J.K., Li, J.M., Gove, C., Lambeth, J.D., Cave, A.C., Shah, A.M. Circ. Res. (2003) [Pubmed]
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