Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Nox4 - NADPH oxidase 4

Mus musculus

Synonyms: AI648021, KOX-1, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase, ...

Ellmark, S.H. et al., Byrne, J.A. et al., Yang, S. et al., Yang, S. et al.

Yang, Zhang, Ries, Key, Yang, Madyastha, Bingel, Ries, Key,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Nox4

In this study, the cloning of a NADPH oxidase subunit (Nox 4) with 578 amino acids is reported [1].
Nox 4 is present and active in osteoclasts [1].
Hence, we examined the role of Nox4, a gp91phox homologue, in superoxide production in mouse-cultured VSMCs [2].
In unstimulated VSMCs, phosphorothioate antisense oligonucleotides against Nox4 down-regulated mRNA expression of the subunit by 65% and attenuated superoxide production by 41% without affecting Nox1 expression [2].
The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle [2].

Anatomical context of Nox4

Expression of Nox4 in osteoclasts [3].

Associations of Nox4 with chemical compounds

These data suggest a differential response of the cardiac Nox isoforms, gp91phox and Nox4, to Ang II versus pressure overload [4].

Regulatory relationships of Nox4

Further study revealed that JNK was activated and that NF-kappa B was inhibited in Nox4/P22 cotransfected osteoclasts [3].

Analytical, diagnostic and therapeutic context of Nox4

Myocardial expression of an alternative gp91phox isoform, Nox4, was upregulated after aortic constriction in gp91phox-/- mice [4].

References

A new superoxide-generating oxidase in murine osteoclasts. Yang, S., Madyastha, P., Bingel, S., Ries, W., Key, L. J. Biol. Chem. (2001) [Pubmed]
The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle. Ellmark, S.H., Dusting, G.J., Fui, M.N., Guzzo-Pernell, N., Drummond, G.R. Cardiovasc. Res. (2005) [Pubmed]
Expression of Nox4 in osteoclasts. Yang, S., Zhang, Y., Ries, W., Key, L. J. Cell. Biochem. (2004) [Pubmed]
Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy. Byrne, J.A., Grieve, D.J., Bendall, J.K., Li, J.M., Gove, C., Lambeth, J.D., Cave, A.C., Shah, A.M. Circ. Res. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP003772	Anopheles gambiae str. PEST
NOX4	Bos taurus
NOX4	Canis lupus familiaris
NOX4	Gallus gallus
NOX4	Homo sapiens
NOX4	Macaca mulatta
NOX4	Pan troglodytes
Nox4	Rattus norvegicus
nox4	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.