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Gene Review

Cybb  -  cytochrome b-245, beta polypeptide

Mus musculus

Synonyms: C88302, CGD91-phox, Cgd, Cyd, Cytochrome b(558) subunit beta, ...
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Disease relevance of Cybb


High impact information on Cybb

  • Greater bacterial numbers were present in the spleens and livers of gp91phox(-/)- mice compared with C57BL/6 controls as early as day 1 of infection, and all of the gp91phox(-/)- mice succumbed to infection within 5 d [5].
  • Mice with X-linked chronic granulomatous disease (CGD) generated by targeted disruption of the gp91phox subunit of the NADPH-oxidase complex (X-CGD mice) were examined for their response to respiratory challenge with Aspergillus fumigatus [6].
  • We addressed this issue by subjecting leukocyte oxidase (Nox2)-deficient (Nox2-/-) mice to arterial injury [7].
  • Femoral artery injury was associated with increased Nox2 expression, ROS/RNS production, and oxidative protein and lipid modification in wild-type mice [7].
  • Nox1, a homologue of gp91phox, the catalytic moiety of the superoxide (O(2)(-))-generating NADPH oxidase of phagocytes, causes increased O(2)(-) generation, increased mitotic rate, cell transformation, and tumorigenicity when expressed in NIH 3T3 fibroblasts [8].

Chemical compound and disease context of Cybb


Biological context of Cybb


Anatomical context of Cybb


Associations of Cybb with chemical compounds


Regulatory relationships of Cybb

  • Deficiency of gp91phox or inhibition of NADH oxidase blocked TNF-alpha expression stimulated by LPS [19].
  • Hypertension induced by 2K1C was more severe in WT than in gp91phox-/- mice (158+/-2 versus 149+/-2 mm Hg; P<0.05) [21].

Other interactions of Cybb

  • This contrasted with Leishmania major infection, which caused rapid lesion growth and death in iNOS knockout mice and some exacerbation of disease with gp91phox deficiency [22].
  • Functional gp91phox and iNOS are required to control S. enterica serovar Typhimurium in non-Slc11a1-regulated phases of infection [22].
  • Deletion of gp91 phox did not alter p22 phox expression but severely inhibited activated O2 species production [1].
  • In the mesenteric arteries the expression of nox4 (4 weeks) and gp91phox (nox2) (8 weeks) subunits of NADPH oxidase from streptozotocin-apoE(-/-) were enhanced as were eNOS mRNA and protein (P<0.05) [23].
  • These data suggest a differential response of the cardiac Nox isoforms, gp91phox and Nox4, to Ang II versus pressure overload [20].

Analytical, diagnostic and therapeutic context of Cybb


  1. O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Archer, S.L., Reeve, H.L., Michelakis, E., Puttagunta, L., Waite, R., Nelson, D.P., Dinauer, M.C., Weir, E.K. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. van de Loo, F.A., Bennink, M.B., Arntz, O.J., Smeets, R.L., Lubberts, E., Joosten, L.A., van Lent, P.L., Coenen-de Roo, C.J., Cuzzocrea, S., Segal, B.H., Holland, S.M., van den Berg, W.B. Am. J. Pathol. (2003) [Pubmed]
  3. Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis. Schaper, M., Leib, S.L., Meli, D.N., Brandes, R.P., Täuber, M.G., Christen, S. Infect. Immun. (2003) [Pubmed]
  4. Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox. Maytin, M., Siwik, D.A., Ito, M., Xiao, L., Sawyer, D.B., Liao, R., Colucci, W.S. Circulation (2004) [Pubmed]
  5. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo. Mastroeni, P., Vazquez-Torres, A., Fang, F.C., Xu, Y., Khan, S., Hormaeche, C.E., Dougan, G. J. Exp. Med. (2000) [Pubmed]
  6. Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus. Morgenstern, D.E., Gifford, M.A., Li, L.L., Doerschuk, C.M., Dinauer, M.C. J. Exp. Med. (1997) [Pubmed]
  7. Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury. Chen, Z., Keaney, J.F., Schulz, E., Levison, B., Shan, L., Sakuma, M., Zhang, X., Shi, C., Hazen, S.L., Simon, D.I. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Arnold, R.S., Shi, J., Murad, E., Whalen, A.M., Sun, C.Q., Polavarapu, R., Parthasarathy, S., Petros, J.A., Lambeth, J.D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  9. Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes. Dinauer, M.C., Deck, M.B., Unanue, E.R. J. Immunol. (1997) [Pubmed]
  10. NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. Zhan, G., Serrano, F., Fenik, P., Hsu, R., Kong, L., Pratico, D., Klann, E., Veasey, S.C. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  11. Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca(2+)](i) and respiratory responses to hypoxia. Roy, A., Rozanov, C., Mokashi, A., Daudu, P., Al-mehdi, A.B., Shams, H., Lahiri, S. Brain Res. (2000) [Pubmed]
  12. High-resolution comparative mapping of the proximal region of the mouse X chromosome. Blair, H.J., Ho, M., Monaco, A.P., Fisher, S., Craig, I.W., Boyd, Y. Genomics (1995) [Pubmed]
  13. Reactive Oxygen Species Derived From NADPH Oxidase System is Not Essential for Liver Regeneration After Partial Hepatectomy. Ueno, S., Campbell, J., Fausto, N. J. Surg. Res. (2006) [Pubmed]
  14. NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. Park, L., Anrather, J., Zhou, P., Frys, K., Pitstick, R., Younkin, S., Carlson, G.A., Iadecola, C. J. Neurosci. (2005) [Pubmed]
  15. Cloning of murine gp91phox cDNA and functional expression in a human X-linked chronic granulomatous disease cell line. Björgvinsdóttir, H., Zhen, L., Dinauer, M.C. Blood (1996) [Pubmed]
  16. Ramipril treatment protects against nitrate-induced oxidative stress in eNOS-/- mice: An implication of the NADPH oxidase pathway. Otto, A., Fontaine, J., Berkenboom, G. J. Cardiovasc. Pharmacol. (2006) [Pubmed]
  17. Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Kazama, K., Anrather, J., Zhou, P., Girouard, H., Frys, K., Milner, T.A., Iadecola, C. Circ. Res. (2004) [Pubmed]
  18. Expression of Nox genes in rat organs, mouse oocytes, and sea urchin eggs. Maru, Y., Nishino, T., Kakinuma, K. DNA Seq. (2005) [Pubmed]
  19. Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression. Peng, T., Lu, X., Feng, Q. Circulation (2005) [Pubmed]
  20. Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy. Byrne, J.A., Grieve, D.J., Bendall, J.K., Li, J.M., Gove, C., Lambeth, J.D., Cave, A.C., Shah, A.M. Circ. Res. (2003) [Pubmed]
  21. gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Jung, O., Schreiber, J.G., Geiger, H., Pedrazzini, T., Busse, R., Brandes, R.P. Circulation (2004) [Pubmed]
  22. Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity. White, J.K., Mastroeni, P., Popoff, J.F., Evans, C.A., Blackwell, J.M. J. Leukoc. Biol. (2005) [Pubmed]
  23. Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: Changes in expression of NADPH oxidase subunits and eNOS. Ding, H., Hashem, M., Triggle, C. Eur. J. Pharmacol. (2007) [Pubmed]
  24. A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Görlach, A., Brandes, R.P., Nguyen, K., Amidi, M., Dehghani, F., Busse, R. Circ. Res. (2000) [Pubmed]
  25. Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells. Lievens, P.M., Donady, J.J., Tufarelli, C., Neufeld, E.J. J. Biol. Chem. (1995) [Pubmed]
  26. Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species. Milovanova, T., Chatterjee, S., Manevich, Y., Kotelnikova, I., Debolt, K., Madesh, M., Moore, J.S., Fisher, A.B. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  27. Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia. Tojo, T., Ushio-Fukai, M., Yamaoka-Tojo, M., Ikeda, S., Patrushev, N., Alexander, R.W. Circulation (2005) [Pubmed]
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