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Gene Review:

NOX4 - NADPH oxidase 4

Bos taurus

Hwang, J. et al., Gupte, S.A. et al.

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High impact information on NOX4

In contrast, pulsatile flow downregulated both gp91phox and Nox4 mRNA expression (by 1.8+/-0.2-fold and 3.0+/-0.12-fold, respectively), with an accompanying reduction in O2-* production, reduction in the extent of LDL modification (51+/-12% for LDL- and 30+/-7% for LDL2-), and monocyte/BAEC binding [1].

Analytical, diagnostic and therapeutic context of NOX4

There was no significant difference in the expression of Nox2 or Nox4 mRNA or protein detected by Western blot analysis [2].

References

Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation. Hwang, J., Ing, M.H., Salazar, A., Lassègue, B., Griendling, K., Navab, M., Sevanian, A., Hsiai, T.K. Circ. Res. (2003) [Pubmed]
Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries. Gupte, S.A., Kaminski, P.M., Floyd, B., Agarwal, R., Ali, N., Ahmad, M., Edwards, J., Wolin, M.S. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]

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AgaP_AGAP003772	Anopheles gambiae str. PEST
NOX4	Canis lupus familiaris
NOX4	Gallus gallus
NOX4	Homo sapiens
NOX4	Macaca mulatta
Nox4	Mus musculus
NOX4	Pan troglodytes
Nox4	Rattus norvegicus
nox4	Xenopus (Silurana) tropicalis

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