Gene Review:
Nox4 - NADPH oxidase 4
Rattus norvegicus
Synonyms:
KOX-1, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, Kox
Colston,
de la Rosa,
Strader,
Anderson,
Freeman,
Wingler,
Wünsch,
Kreutz,
Rothermund,
Paul,
Schmidt,
Gorin,
Block,
Hernandez,
Bhandari,
Wagner,
Barnes,
Abboud,
Ago,
Kitazono,
Kuroda,
Kumai,
Kamouchi,
Ooboshi,
Wakisaka,
Kawahara,
Rokutan,
Ibayashi,
Iida,
Nishiyama,
Yao,
Nagai,
Miyata,
Yoshizumi,
Kagami,
Kondo,
Kiyomoto,
Shokoji,
Kimura,
Kohno,
Abe,
Li,
Witte,
August,
Brausch,
Gödtel-Armbrust,
Habermeier,
Closs,
Oelze,
Münzel,
Förstermann,
- Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. Gorin, Y., Block, K., Hernandez, J., Bhandari, B., Wagner, B., Barnes, J.L., Abboud, H.E. J. Biol. Chem. (2005)
- Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo. Paravicini, T.M., Chrissobolis, S., Drummond, G.R., Sobey, C.G. Stroke (2004)
- Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo. Wingler, K., Wünsch, S., Kreutz, R., Rothermund, L., Paul, M., Schmidt, H.H. Free Radic. Biol. Med. (2001)
- Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. Gorin, Y., Ricono, J.M., Kim, N.H., Bhandari, B., Choudhury, G.G., Abboud, H.E. Am. J. Physiol. Renal Physiol. (2003)
- Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase. Ago, T., Kitazono, T., Ooboshi, H., Iyama, T., Han, Y.H., Takada, J., Wakisaka, M., Ibayashi, S., Utsumi, H., Iida, M. Circulation (2004)
- H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts. Colston, J.T., de la Rosa, S.D., Strader, J.R., Anderson, M.A., Freeman, G.L. FEBS Lett. (2005)
- Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Hilenski, L.L., Clempus, R.E., Quinn, M.T., Lambeth, J.D., Griendling, K.K. Arterioscler. Thromb. Vasc. Biol. (2004)
- NAD(P)H oxidases in rat basilar arterial endothelial cells. Ago, T., Kitazono, T., Kuroda, J., Kumai, Y., Kamouchi, M., Ooboshi, H., Wakisaka, M., Kawahara, T., Rokutan, K., Ibayashi, S., Iida, M. Stroke (2005)
- Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Nishiyama, A., Yao, L., Nagai, Y., Miyata, K., Yoshizumi, M., Kagami, S., Kondo, S., Kiyomoto, H., Shokoji, T., Kimura, S., Kohno, M., Abe, Y. Hypertension (2004)
- Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. Li, H., Witte, K., August, M., Brausch, I., Gödtel-Armbrust, U., Habermeier, A., Closs, E.I., Oelze, M., Münzel, T., Förstermann, U. J. Am. Coll. Cardiol. (2006)
- NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Miller, A.A., Drummond, G.R., Schmidt, H.H., Sobey, C.G. Circ. Res. (2005)