Gene Review:
VTN - vitronectin
Bos taurus
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High impact information on VTN
- Taken together, these data suggest that the snake venom disintegrin CTS is a potent inhibitor of beta3 integrin-mediated osteoclast attachment, presumably involving the VTN receptor (an alpha[v]beta3 integrin) [1].
- Only MAb F11 inhibited attachment to immobilized CTS (IC50 = 0.41 +/- 0.12 microg/ml), suggesting that binding to CTS is mediated in part by a beta3 integrin, presumably the alpha(v)beta3 VTN receptor [1].
Anatomical context of VTN
- Further, CTS was observed to inhibit completely osteoclast attachment to fetal bovine serum (FBS; IC50,FBS = 0.36 +/- 0.04 nM) and VTN (IC50,VTN = 0.85 +/- 0.13 nM) [1].
References
- Contortrostatin, a homodimeric snake venom disintegrin, is a potent inhibitor of osteoclast attachment. Mercer, B., Markland, F., Minkin, C. J. Bone Miner. Res. (1998) [Pubmed]
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