Gene Review:
Vtn - vitronectin
Mus musculus
Synonyms:
AI256434, S-protein, Serum-spreading factor, VN, Vitronectin, ...
- Intact vitronectin induces matrix metalloproteinase-2 and tissue inhibitor of metalloproteinases-2 expression and enhanced cellular invasion by melanoma cells. Bafetti, L.M., Young, T.N., Itoh, Y., Stack, M.S. J. Biol. Chem. (1998)
- A new type of antimetastatic peptide derived from fibronectin. Kato, R., Ishikawa, T., Kamiya, S., Oguma, F., Ueki, M., Goto, S., Nakamura, H., Katayama, T., Fukai, F. Clin. Cancer Res. (2002)
- Plasminogen activator inhibitor 1 and vitronectin protect against stenosis in a murine carotid artery ligation model. de Waard, V., Arkenbout, E.K., Carmeliet, P., Lindner, V., Pannekoek, H. Arterioscler. Thromb. Vasc. Biol. (2002)
- Vitronectin inhibits the thrombotic response to arterial injury in mice. Fay, W.P., Parker, A.C., Ansari, M.N., Zheng, X., Ginsburg, D. Blood (1999)
- Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice. Eitzman, D.T., Westrick, R.J., Nabel, E.G., Ginsburg, D. Blood (2000)
- Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. Tsuruta, Y., Park, Y.J., Siegal, G.P., Liu, G., Abraham, E. J. Immunol. (2007)
- Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes. Chavakis, T., Hussain, M., Kanse, S.M., Peters, G., Bretzel, R.G., Flock, J.I., Herrmann, M., Preissner, K.T. Nat. Med. (2002)
- Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Freire-de-Lima, C.G., Nascimento, D.O., Soares, M.B., Bozza, P.T., Castro-Faria-Neto, H.C., de Mello, F.G., DosReis, G.A., Lopes, M.F. Nature (2000)
- Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization. Hammes, H.P., Brownlee, M., Jonczyk, A., Sutter, A., Preissner, K.T. Nat. Med. (1996)
- Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Stephens, L.E., Sutherland, A.E., Klimanskaya, I.V., Andrieux, A., Meneses, J., Pedersen, R.A., Damsky, C.H. Genes Dev. (1995)
- Inhibition of metastatic cell colonization in murine lungs and tumor-induced morbidity by non-peptidic Arg-Gly-Asp mimetics. Hardan, I., Weiss, L., Hershkoviz, R., Greenspoon, N., Alon, R., Cahalon, L., Reich, S., Slavin, S., Lider, O. Int. J. Cancer (1993)
- Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: differences in integrin signaling during cell adhesion to osteopontin versus vitronectin. Ding, Q., Stewart, J., Prince, C.W., Chang, P.L., Trikha, M., Han, X., Grammer, J.R., Gladson, C.L. Cancer Res. (2002)
- Effects of the novel alphav integrin antagonist SM256 and cis-platinum on growth of murine squamous cell carcinoma PAM LY8. Van Waes, C., Enamorado-Ayala, I., Hecht, D., Sulica, L., Chen, Z., Batt, D.G., Mousa, S. Int. J. Oncol. (2000)
- Thrombotic phenotype of mice with a combined deficiency in plasminogen activator inhibitor 1 and vitronectin. Koschnick, S., Konstantinides, S., Schäfer, K., Crain, K., Loskutoff, D.J. J. Thromb. Haemost. (2005)
- Isolation and characterization of murine clonogenic osteoclast progenitors by cell surface phenotype analysis. Muguruma, Y., Lee, M.Y. Blood (1998)
- Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels. Arcangeli, A., Becchetti, A., Mannini, A., Mugnai, G., De Filippi, P., Tarone, G., Del Bene, M.R., Barletta, E., Wanke, E., Olivotto, M. J. Cell Biol. (1993)
- Specific reduction in osteopontin synthesis by antisense RNA inhibits the tumorigenicity of transformed Rat1 fibroblasts. Gardner, H.A., Berse, B., Senger, D.R. Oncogene (1994)
- Plasminogen activator inhibitor-1 impairs alveolar epithelial repair by binding to vitronectin. Lazar, M.H., Christensen, P.J., Du, M., Yu, B., Subbotina, N.M., Hanson, K.E., Hansen, J.M., White, E.S., Simon, R.H., Sisson, T.H. Am. J. Respir. Cell Mol. Biol. (2004)
- Vitronectin and fibronectin function as glucan binding proteins augmenting macrophage responses to Pneumocystis carinii. Vassallo, R., Kottom, T.J., Standing, J.E., Limper, A.H. Am. J. Respir. Cell Mol. Biol. (2001)
- Differential phosphorylation of paxillin in response to surface-bound serum proteins during early osteoblast adhesion. Sommerfeldt, D.W., McLeod, K.J., Rubin, C.T., Hadjiargyrou, M. Biochem. Biophys. Res. Commun. (2001)
- The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies. Bajou, K., Masson, V., Gerard, R.D., Schmitt, P.M., Albert, V., Praus, M., Lund, L.R., Frandsen, T.L., Brunner, N., Dano, K., Fusenig, N.E., Weidle, U., Carmeliet, G., Loskutoff, D., Collen, D., Carmeliet, P., Foidart, J.M., Noël, A. J. Cell Biol. (2001)
- ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin. Roberts, M.S., Woods, A.J., Shaw, P.E., Norman, J.C. J. Biol. Chem. (2003)
- Cell cycle-mediated regulation of smooth muscle alpha-actin gene transcription in fibroblasts and vascular smooth muscle cells involves multiple adenovirus E1A-interacting cofactors. Wang, S.X., Elder, P.K., Zheng, Y., Strauch, A.R., Kelm, R.J. J. Biol. Chem. (2005)
- Assay of oxysterol-binding protein in a mouse fibroblast, cell-free system. Dissociation constant and other properties of the system. Kandutsch, A.A., Shown, E.P. J. Biol. Chem. (1981)
- Conformational lability of vitronectin: induction of an antigenic change by alpha-thrombin-serpin complexes and by proteolytically modified thrombin. Tomasini, B.R., Owen, M.C., Fenton, J.W., Mosher, D.F. Biochemistry (1989)
- Plasminogen activator inhibitor type-1 inhibits insulin signaling by competing with alphavbeta3 integrin for vitronectin binding. López-Alemany, R., Redondo, J.M., Nagamine, Y., Muñoz-Cánoves, P. Eur. J. Biochem. (2003)
- Alphavbeta3 integrin and cofilin modulate K1735 melanoma cell invasion. Dang, D., Bamburg, J.R., Ramos, D.M. Exp. Cell Res. (2006)
- Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. Brooks, P.C., Klemke, R.L., Schon, S., Lewis, J.M., Schwartz, M.A., Cheresh, D.A. J. Clin. Invest. (1997)
- Survival of 3T3-L1 cells induced by fibroblast growth factor depends on cell density and adhesion to the substratum. Shiba, Y., Yamada, S., Kanno, Y. Cell Struct. Funct. (1989)
- Mouse hepatitis virus neurovirulence: evidence of a linkage between S glycoprotein expression and immunopathology. Rempel, J.D., Murray, S.J., Meisner, J., Buchmeier, M.J. Virology (2004)
- Assembly of exogenous fibronectin by fibronectin-null cells is dependent on the adhesive substrate. Bae, E., Sakai, T., Mosher, D.F. J. Biol. Chem. (2004)
- Detection of vitronectin mRNA in tissues and cells of the mouse. Seiffert, D., Keeton, M., Eguchi, Y., Sawdey, M., Loskutoff, D.J. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Vitronectin is not essential for normal mammalian development and fertility. Zheng, X., Saunders, T.L., Camper, S.A., Samuelson, L.C., Ginsburg, D. Proc. Natl. Acad. Sci. U.S.A. (1995)