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Gene Review

Vtn  -  vitronectin

Rattus norvegicus

Synonyms: Aa1018, Vn
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Disease relevance of Vtn

  • In initial experiments, Vn levels were measured during the surgically induced acute phase response in humans [1].
  • When BSP was used as an affinity matrix to isolate a cell surface receptor from rat osteosarcoma cells, a protein composed of polypeptides similar in size to those of a previously characterized vitronectin receptor was obtained [2].
  • The leading edges of migrating osteoclasts, and the attachment structure, a broad vinculin band, which forms before bone resorption, also expressed vitronectin receptor, particularly when the antibody against the alpha v subunit was used.(ABSTRACT TRUNCATED AT 250 WORDS)[3]
  • Pretreatment of PVG/c+ rats with antibodies against vitronectin, followed by administration of ER4G, resulted in the immediate development of proteinuria (maximum, 119 mg/24 h on day 3; P < 0.05), whereas Wistar rats did not become more proteinuric [4].
  • All these effects were inhibited by pertussis toxin, or by antibodies directed against the urokinase receptor (uPAR) or against the VN receptor alpha(v)beta(3) suggesting that an association between the two receptors is required to mediate both signals [5].

High impact information on Vtn

  • Silicone elastomer strain plates were coated at varying densities with elastin, laminin, type I collagen, fibronectin, or vitronectin [6].
  • Overexpression of TAP20 decreased cell adhesion and enhanced migration on vitronectin and tube formation in three-dimensional culture [7].
  • Vitronectin at sites of cell-substrate contact in cultures of rat myotubes [8].
  • Our results are consistent with the hypothesis that vitronectin is present at all sites of cell-substrate contact, but that its antigenic sites are obscured by material deposited by both myotube and fibroblast cells [8].
  • Furthermore, the vitronectin receptor, which has known specificity for osteopontin, is shown preferentially localized at the corresponding area of the osteoclast plasma membrane [9].

Chemical compound and disease context of Vtn


Biological context of Vtn

  • To characterize the primary structure of rat Vn, a cDNA library constructed from freshly isolated rat hepatocytes, was screened with a human Vn cDNA probe [13].
  • Vitronectin, an ECM component that is generally prominent in wound healing, has been detected in PCO specimens [14].
  • Here we set out to investigate the distribution of vitronectin in the lens and determine how it, and other ECM components, influence the lens epithelial phenotype [14].
  • Vitronectin and its integrin receptor subunits alpha(v) are expressed in the inner part of the external germinal layer where granule cell precursors exit the cell cycle and commence differentiation [15].
  • Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation [15].

Anatomical context of Vtn

  • To specify the liver cell type involved in the biosynthesis of Vn, we used a competitive PCR-assay to discriminate between expression levels [13].
  • We found that expression of Vn in hepatocytes is at least 1000-fold higher than in Kupffer cells and 3000-fold higher than in endothelial liver cells [13].
  • Vitronectin is present in epithelial cells of the intact lens and promotes epithelial mesenchymal transition in lens epithelial explants [14].
  • In explants cultured on vitronectin and fibronectin, but not laminin, cell nuclei showed prominent reactivity for Smad 2/3 [14].
  • Oligodendrocytes bound to surfaces coated with fibronectin, vitronectin and a protein component of the glial matrix [16].

Associations of Vtn with chemical compounds


Physical interactions of Vtn

  • Vitronectin receptor (alpha(v)beta(3)) blockade interferes with binding of this integrin to MMP-2 and proteolyzed collagen, thereby reducing cell invasion [20].

Regulatory relationships of Vtn


Other interactions of Vtn


Analytical, diagnostic and therapeutic context of Vtn


  1. IL-6 stimulates vitronectin gene expression in vivo. Seiffert, D., Geisterfer, M., Gauldie, J., Young, E., Podor, T.J. J. Immunol. (1995) [Pubmed]
  2. Identification of a bone sialoprotein receptor in osteosarcoma cells. Oldberg, A., Franzén, A., Heinegård, D., Pierschbacher, M., Ruoslahti, E. J. Biol. Chem. (1988) [Pubmed]
  3. Spatial organization of microfilaments and vitronectin receptor, alpha v beta 3, in osteoclasts. A study using confocal laser scanning microscopy. Lakkakorpi, P.T., Helfrich, M.H., Horton, M.A., Väänänen, H.K. J. Cell. Sci. (1993) [Pubmed]
  4. Anti-vitronectin antibodies enhance anti-Thy-1-induced proteinuria in PVG/c, but not in Wistar rats. Van Dixhoorn, M.G., Salazar-Exaire, D., Sato, T., Daha, M.R., Quigg, R.J., Bruijn, J.A., Couser, W.G., De Heer, E. J. Am. Soc. Nephrol. (1998) [Pubmed]
  5. Urokinase/urokinase receptor and vitronectin/alpha(v)beta(3) integrin induce chemotaxis and cytoskeleton reorganization through different signaling pathways. Degryse, B., Orlando, S., Resnati, M., Rabbani, S.A., Blasi, F. Oncogene (2001) [Pubmed]
  6. Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions. Wilson, E., Sudhir, K., Ives, H.E. J. Clin. Invest. (1995) [Pubmed]
  7. Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein. Tang, S., Gao, Y., Ware, J.A. J. Cell Biol. (1999) [Pubmed]
  8. Vitronectin at sites of cell-substrate contact in cultures of rat myotubes. Baetscher, M., Pumplin, D.W., Bloch, R.J. J. Cell Biol. (1986) [Pubmed]
  9. Osteopontin--a possible anchor of osteoclasts to bone. Reinholt, F.P., Hultenby, K., Oldberg, A., Heinegård, D. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  10. Complex gangliosides modulate the integrin-mediated adhesion in a rat hepatoma cell line. Barletta, E., Mugnai, G., Ruggieri, S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  11. The interaction of vascular endothelial cells and dorsal root ganglion neurites is mediated by vitronectin and heparan sulfate proteoglycans. Isahara, K., Yamamoto, M. Brain Res. Dev. Brain Res. (1995) [Pubmed]
  12. Alterations of vitronectin and its receptor alpha(v) integrin in the rat renal glomerular wall during diabetes. Yoon, S., Gingras, D., Bendayan, M. Am. J. Kidney Dis. (2001) [Pubmed]
  13. Hepatocellular localisation of biosynthesis of vitronectin. Characterisation of the primary structure of rat vitronectin. Otter, M., Kuiper, J., Rijken, D., van Zonneveld, A.J. Biochem. Mol. Biol. Int. (1995) [Pubmed]
  14. Vitronectin is present in epithelial cells of the intact lens and promotes epithelial mesenchymal transition in lens epithelial explants. Taliana, L., Evans, M.D., Ang, S., McAvoy, J.W. Mol. Vis. (2006) [Pubmed]
  15. Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation. Pons, S., Trejo, J.L., Martínez-Morales, J.R., Martí, E. Development (2001) [Pubmed]
  16. Evidence that an RGD-dependent receptor mediates the binding of oligodendrocytes to a novel ligand in a glial-derived matrix. Cardwell, M.C., Rome, L.H. J. Cell Biol. (1988) [Pubmed]
  17. Ligation of endothelial alpha v beta 3 integrin increases capillary hydraulic conductivity of rat lung. Tsukada, H., Ying, X., Fu, C., Ishikawa, S., McKeown-Longo, P., Albelda, S., Bhattacharya, S., Bray, B.A., Bhattacharya, J. Circ. Res. (1995) [Pubmed]
  18. Extracellular matrix remodeling at the early stages of liver regeneration in the rat. Kim, T.H., Mars, W.M., Stolz, D.B., Petersen, B.E., Michalopoulos, G.K. Hepatology (1997) [Pubmed]
  19. Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion. Pierschbacher, M.D., Ruoslahti, E. J. Biol. Chem. (1987) [Pubmed]
  20. Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of alpha(v)beta(3) receptor blockade. Margolin, L., Fishbein, I., Banai, S., Golomb, G., Reich, R., Perez, L.S., Gertz, S.D. Atherosclerosis (2002) [Pubmed]
  21. Suppression of integrin alpha(v) expression by endothelin-1 in vascular smooth muscle cells. Doi, M., Shichiri, M., Yoshida, M., Marumo, F., Hirata, Y. Hypertens. Res. (2000) [Pubmed]
  22. Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2. Stefansson, S., Lawrence, D.A., Argraves, W.S. J. Biol. Chem. (1996) [Pubmed]
  23. Inhibition of rat mast cell protease 1 by vitronectin. Pejler, G., Tomasini-Johansson, B.R. FEBS Lett. (1994) [Pubmed]
  24. Role of vitronectin in embryonic rat endocardial cell migration in vitro. Sumida, H., Nakamura, H., Yasuda, M. Cell Tissue Res. (1992) [Pubmed]
  25. Vitronectin overrides a negative effect of TNF-alpha on astrocyte migration. Faber-Elman, A., Lavie, V., Schvartz, I., Shaltiel, S., Schwartz, M. FASEB J. (1995) [Pubmed]
  26. Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant. Inagaki, K., Noguchi, T., Matozaki, T., Horikawa, T., Fukunaga, K., Tsuda, M., Ichihashi, M., Kasuga, M. Oncogene (2000) [Pubmed]
  27. Protective effect of nafamostat mesilate in early wound healing. Tsutamoto, Y., Tani, T., Eguchi, Y., Araki, H., Kodama, M. J. Am. Coll. Surg. (1997) [Pubmed]
  28. Modulation of calcium current in arteriolar smooth muscle by alphav beta3 and alpha5 beta1 integrin ligands. Wu, X., Mogford, J.E., Platts, S.H., Davis, G.E., Meininger, G.A., Davis, M.J. J. Cell Biol. (1998) [Pubmed]
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