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Gene Review:

Orc3 - origin recognition complex, subunit 3

Mus musculus

Synonyms: Orc3l, Origin recognition complex subunit 3, Origin recognition complex subunit Latheo

Miyake, Y. et al., Springer, J. et al.

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High impact information on Orc3l

Taken together, we conclude that mouse Orc1, Orc2, and Orc3 each exist in two alternative-splicing variants and that naturally occurring Orc1B lacks a functional domain that is essential for nuclear translocation and proteasome-dependent degradation [1].
To define the physiological functions of the mammalian ORC, we cloned ORC subunit cDNAs from mouse NIH3T3 cells and found novel variant forms of Orc1, Orc2, and Orc3 each derived from alternative RNA splicing [1].
The mouse ORC3 gene Orc3 was assigned to mouse chromosome 4A3 by fluorescence in situ hybridization (FISH) analysis [2].

References

Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation. Miyake, Y., Mizuno, T., Yanagi, K., Hanaoka, F. J. Biol. Chem. (2005) [Pubmed]
Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex. Springer, J., Nanda, I., Hoehn, K., Schmid, M., Grummt, F. Cytogenet. Cell Genet. (1999) [Pubmed]

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AgaP_AGAP010406	Anopheles gambiae str. PEST
ORC3	Arabidopsis thaliana
ORC3	Bos taurus
ORC3	Canis lupus familiaris
orc3	Danio rerio
lat	Drosophila melanogaster
ORC3	Gallus gallus
ORC3	Homo sapiens
MGG_04410	Magnaporthe oryzae 70-15
NCU02683	Neurospora crassa OR74A
Os10g0402200	Oryza sativa Japonica Group
ORC3	Pan troglodytes
Orc3	Rattus norvegicus
orc3	Xenopus (Silurana) tropicalis

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