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Gene Review

ORC3  -  origin recognition complex, subunit 3

Homo sapiens

Synonyms: IMAGE50150, LAT, LATHEO, ORC3L, Origin recognition complex subunit 3, ...
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Disease relevance of ORC3L

  • Expression of a beta-glucuronidase gene driven by the LAT promoter was tested in mice lacking this enzyme, which are a model for a human genetic disease affecting the CNS (mucopolysaccharidosis VII, Sly disease) [1].
  • Herpesviruses establish latent infections in neurons during which only one viral gene (LAT) is expressed, thus the LAT promoter may express foreign genes in latently infected CNS cells [1].
  • To address the possibility of neuronal-like herpes simplex virus type 1 (HSV-1) latency in the cornea by determining if regulation of the HSV-1 LAT promoter in stromal keratocytes is similar to LAT promoter regulation in neurons [2].
  • With a combination of Dipstick and LAT, all abscess and colitis patients had at least one positive result [3].
  • In the laboratory diagnosis of pharyngitis, results from latex agglutination tests (LAT) performed directly on throat swabs are often compared with the isolation of group A beta-hemolytic streptococci (GABHS) from simultaneously obtained swabs cultivated on a variety of media under different atmospheric conditions [4].

High impact information on ORC3L

  • T cell anergy: where it's LAT [5].
  • In addition, the maintenance of the resulting contact requires sustained calcium influxes, an intact microtubule cytoskeleton, and functional LAT [6].
  • Orc2, Orc3, and Orc5 also are detected in non-proliferating cells like cardiac myocytes, adrenal cortical cells, and neurons, suggesting an additional role of these proteins in non-proliferating cells [7].
  • In addition, patients had reduced activities of both carnitine palmitoyltransferase (CPT) and glycerophospholipid acyltransferase (LAT; CoA dependent), and increased ratios of long-chain acylcarnitine (LCAC) to free carnitine in their erythrocytes [8].
  • In the presence of IgG, S. sanguis strain 2017-78 caused the tyrosine phosphorylation of FcgammaRIIA 30s following stimulation, which led to the phosphorylation of Syk, LAT, and PLCgamma2 [9].

Chemical compound and disease context of ORC3L


Biological context of ORC3L

  • The recombinant vector virus, which has the foreign gene substituted into the viral LAT locus, had reduced pathogenicity after corneal inoculation compared to the wild-type virus from which it was derived (HSV-1 strain 17+) [14].
  • The structural features of the LAT IGHG3 allele, which are the lack of one hinge exon and its conversion by the IGHG4 gene, demonstrate that both crossing-over and gene conversion events occur in the evolution of the human IGHG genes [15].
  • The LAT was evaluated with the hemagglutination inhibition (HI) assay as the reference test [16].
  • In a randomised, single blind, placebo-controlled crossover design study, we investigated whether healthy, non-smoking, dietary unrestrained women (n 24), divided into linoleic acid tasters (LAT, n 14) and linoleic acid non-tasters (LANT, n 10), differed in food intake regulation when linoleic acid was added to ice creams [17].
  • However, since the bias is appreciably greater at lower LAT values (likely because VCO2 kinetics are slower than VO2 kinetics), we separated the studies into two groups: (A) tests where LAT occurred within the first 2 min of the increasing work rate period, and (B) tests where LAT occurred after 2 min [12].

Anatomical context of ORC3L


Associations of ORC3L with chemical compounds

  • The purpose of the present study is to compare LAT gel (4% lidocaine, 1:2000 adrenaline, 0.5% tetracaine) to TAC gel (0.5% tetracaine, 1:2000 adrenaline, 11.8% cocaine) for efficacy, side effects, and costs in children aged 5 to 17 years with facial or scalp lacerations [23].
  • 2',3'-Lyxoanhydrothymidine (LAT), a conformationally restricted inhibitor of retroviral reverse transcriptases, has been studied by X-ray analysis [24].
  • The inhibitory action of hydrocortisone may give new insights into the regulatory mechanisms involved in LAT expression [25].
  • In this review, we focus on the animal members of the LAT cluster that form, together with some of the nematode members, the family of glycoprotein-associated amino acid transporters (gpaAT family) [26].
  • By contrast, ketone homodimers and cross-coupling products arising from reaction through the thienyl 5-position were obtained when using BT and SUP methyl ester; this is very interesting, because stable LAT-derived products are difficult to isolate [27].

Analytical, diagnostic and therapeutic context of ORC3L

  • We compared the performance of Staphychrom II (International Microbio, Signes, France), a rapid (2-h) chromogenic staphylocoagulase test that uses human prothrombin and protease inhibitors, with those of the reference tube coagulase test (TCT) and the latex agglutination test (LAT) Slidex Staph Plus for the rapid identification of S. aureus [28].
  • The sensitivities of the ELISA, Dipstick, and LAT were all 93.3% (42/45) [3].
  • Thus the specificity of ICT also was 100% (321 of 321), although negativity of ICT was not confirmed by PCR, if it was positive for other organisms either by culture or LAT [29].
  • OBJECTIVE: To compare quantitative nephelometry to the traditional semiquantitative latex agglutination (LAT) test for rheumatoid factor (RF) [30].
  • Reproducibility of lateral spine dual energy X-ray absorptiometry (LAT DEXA) scans using a Lunar DPX-L scanner was assessed in a cadaveric phantom and in patients [31].


  1. Herpesvirus vector gene transfer and expression of beta-glucuronidase in the central nervous system of MPS VII mice. Wolfe, J.H., Deshmane, S.L., Fraser, N.W. Nat. Genet. (1992) [Pubmed]
  2. Similarities in regulation of the HSV-1 LAT promoter in corneal and neuronal cells. Perng, G.C., Zwaagstra, J.C., Ghiasi, H., Kaiwar, R., Brown, D.J., Nesburn, A.B., Wechsler, S.L. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  3. Use of rapid dipstick and latex agglutination tests and enzyme-linked immunosorbent assay for serodiagnosis of amebic liver abscess, amebic Colitis, and Entamoeba histolytica Cyst Passage. van Doorn, H.R., Hofwegen, H., Koelewijn, R., Gilis, H., Peek, R., Wetsteyn, J.C., van Genderen, P.J., Vervoort, T., van Gool, T. J. Clin. Microbiol. (2005) [Pubmed]
  4. Effect of medium and cultivation conditions on comparisons between latex agglutination and culture detection of group A streptococci. Graham, L., Meier, F.A., Centor, R.M., Garner, B.K., Dalton, H.P. J. Clin. Microbiol. (1986) [Pubmed]
  5. T cell anergy: where it's LAT. Lineberry, N., Fathman, C.G. Immunity (2006) [Pubmed]
  6. Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Bunnell, S.C., Kapoor, V., Trible, R.P., Zhang, W., Samelson, L.E. Immunity (2001) [Pubmed]
  7. Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins. Thome, K.C., Dhar, S.K., Quintana, D.G., Delmolino, L., Shahsafaei, A., Dutta, A. J. Biol. Chem. (2000) [Pubmed]
  8. Effects of L-carnitine on erythrocyte acyl-CoA, free CoA, and glycerophospholipid acyltransferase in uremia. de los Reyes, B., Navarro, J.A., Pérez-García, R., Liras, A., Campos, Y., Bornstein, B., Arenas, J. Am. J. Clin. Nutr. (1998) [Pubmed]
  9. Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3. Pampolina, C., McNicol, A. Thromb. Haemost. (2005) [Pubmed]
  10. Correlation of penicillin Binding protein 2a detection with oxacillin resistance in Staphylococcus aureus and discovery of a novel penicillin binding protein 2a mutation. Bressler, A.M., Williams, T., Culler, E.E., Zhu, W., Lonsway, D., Patel, J.B., Nolte, F.S. J. Clin. Microbiol. (2005) [Pubmed]
  11. Development of a latex agglutination test for rapid identification of Escherichia coli. Huang, Y.H., Chang, H.C., Chang, T.C. Eur. J. Clin. Microbiol. Infect. Dis. (2001) [Pubmed]
  12. Comparison of gas exchange, lactate, and lactic acidosis thresholds in patients with chronic obstructive pulmonary disease. Patessio, A., Casaburi, R., Carone, M., Appendini, L., Donner, C.F., Wasserman, K. Am. Rev. Respir. Dis. (1993) [Pubmed]
  13. Changes in skeletal muscle oxygenation during incremental exercise measured with near infrared spectroscopy. Belardinelli, R., Barstow, T.J., Porszasz, J., Wasserman, K. European journal of applied physiology and occupational physiology. (1995) [Pubmed]
  14. Increased susceptibility to the pathogenic effects of wild-type and recombinant herpesviruses in MPS VII mice compared to normal siblings. Wolfe, J.H., Martin, C.E., Deshmane, S.L., Reilly, J.J., Kesari, S., Fraser, N.W. J. Neurovirol. (1996) [Pubmed]
  15. A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons. Huck, S., Lefranc, G., Lefranc, M.P. Immunogenetics (1989) [Pubmed]
  16. Development of a specific latex agglutination test based on a recombinant hemagglutinin protein to detect antibodies to H5 avian influenza viruses. Yu, Z., Jin, M., Xu, X., Zhang, R., Zhou, H., Hu, Q., Wu, H., Qin, B., Tan, Y., Chen, H. Avian Dis. (2006) [Pubmed]
  17. The effect of addition of linoleic acid on food intake regulation in linoleic acid tasters and linoleic acid non-tasters. Kamphuis, M.M., Saris, W.H., Westerterp-Plantenga, M.S. Br. J. Nutr. (2003) [Pubmed]
  18. L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier. Tomi, M., Mori, M., Tachikawa, M., Katayama, K., Terasaki, T., Hosoya, K. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  19. Failure of dithiothreitol and pronase to reveal a false-positive cryptococcal antigen determination in cerebrospinal fluid. Sachs, M.K., Huang, C.M., Ost, D., Jungkind, D.L. Am. J. Clin. Pathol. (1991) [Pubmed]
  20. T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains. Brdiĉka, T., Cerný, J., Horejŝí, V. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  21. Stimulation of movement and acrosome reaction of human spermatozoa by PC12 liposomes encapsulating ATP. Skiba-Lahiani, M., Auger, J., Terribile, J., Fattal, E., Delattre, J., Puisieux, F., Jouannet, P. Int. J. Androl. (1995) [Pubmed]
  22. Latex agglutination test: an adjunct to the laboratory diagnosis of pyogenic bacterial meningitis. Mirdha, B.R., Gupta, U., Bhujwala, R.A. Indian journal of pediatrics. (1991) [Pubmed]
  23. Lidocaine adrenaline tetracaine gel versus tetracaine adrenaline cocaine gel for topical anesthesia in linear scalp and facial lacerations in children aged 5 to 17 years. Ernst, A.A., Marvez, E., Nick, T.G., Chin, E., Wood, E., Gonzaba, W.T. Pediatrics (1995) [Pubmed]
  24. X-ray analysis of 2',3'-lyxoanhydrothymidine, a conformationally restricted inhibitor of retroviral reverse transcriptases. Gurskaya, G.V., Bochkarev, A.V., Zdanov, A.S., Papchikhin, A.V., Purygin, P.P., Krayevsky, A.A. FEBS Lett. (1990) [Pubmed]
  25. The mitogen-induced lysophospholipid:acyl-CoA acyltransferase (LAT) expression in human T-lymphocytes is diminished by hydrocortisone. Kerkhoff, C., Gehring, L., Habben, K., Resch, K., Kaever, V. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  26. New glycoprotein-associated amino acid transporters. Verrey, F., Jack, D.L., Paulsen, I.T., Saier, M.H., Pfeiffer, R. J. Membr. Biol. (1999) [Pubmed]
  27. Photoreaction between benzoylthiophenes and N-BOC-tryptophan methyl ester. Pérez-Prieto, J., Morant-Miñana, M.C., Galian, R.E., Miranda, M.A. Photochem. Photobiol. (2006) [Pubmed]
  28. Specific identification of Staphylococcus aureus by Staphychrom II, a rapid chromogenic staphylocoagulase test. Fonsale, N., Bes, M., Verdier, I., Carricajo, A., Ploton, C., Aubert, G., Etienne, J., Vandenesch, F., Freydiere, A.M. J. Clin. Microbiol. (2004) [Pubmed]
  29. Rapid diagnosis of pneumococcal meningitis: implications for treatment and measuring disease burden. Saha, S.K., Darmstadt, G.L., Yamanaka, N., Billal, D.S., Nasreen, T., Islam, M., Hamer, D.H. Pediatr. Infect. Dis. J. (2005) [Pubmed]
  30. In the era of nephelometry, latex agglutination is still good enough to detect rheumatoid factor. Anuradha, V., Chopra, A. J. Rheumatol. (2005) [Pubmed]
  31. Reproducibility of lateral spine scans using dual energy X-ray absorptiometry. Larnach, T.A., Boyd, S.J., Smart, R.C., Butler, S.P., Rohl, P.G., Diamond, T.H. Calcif. Tissue Int. (1992) [Pubmed]
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