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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ACE2  -  angiotensin I converting enzyme (peptidyl...

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High impact information on ACE2

  • Induction of angiotensinogen and decrease in ACE2 levels may be involved in this NF-kappaB-dependent increase in angiotensin II [1].
  • The ratios found for ACE1, ACE2, ACEInt1 and ACEInt2 in the present study were similar to those described above, suggesting that mesangial cells, besides showing the presence of intracellular ACE, are able to secret both full-length wild-type ACE and N-domain ACE [2].
 

Analytical, diagnostic and therapeutic context of ACE2

  • The concentrated medium was submitted to gel filtration on an AcA-34 column and two peaks (ACE1, mol. wt 130 000 and ACE2, 60000) with ACE on activity Hippuryl-His-Leu and Z-Phe-His-Leu were separated [2].

References

  1. NF-kappaB-dependent increase in intrarenal angiotensin II induced by proteinuria. Takase, O., Marumo, T., Imai, N., Hirahashi, J., Takayanagi, A., Hishikawa, K., Hayashi, M., Shimizu, N., Fujita, T., Saruta, T. Kidney Int. (2005) [Pubmed]
  2. Purification and characterization of angiotensin I-converting enzymes from mesangial cells in culture. Andrade, M.C., Quinto, B.M., Carmona, A.K., Ribas, O.S., Boim, M.A., Schor, N., Casarini, D.E. J. Hypertens. (1998) [Pubmed]
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