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MeSH Review

Mesangial Cells

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Disease relevance of Mesangial Cells


High impact information on Mesangial Cells


Chemical compound and disease context of Mesangial Cells


Biological context of Mesangial Cells


Anatomical context of Mesangial Cells

  • We therefore examined the influence of platelet-activating factor (PAF), (a mediator of inflammation released from leukocytes) and of phagocytosis of zymosan on arachidonic acid metabolism and on cell contractility in rat glomerular mesangial cells in culture [20].
  • We show here that, contrary to the situation in T cells, FK506 activates transcription factor NF-kappaB in nonlymphoid cells such as fibroblasts and renal mesangial cells [21].
  • ET-1 (greater than or equal to 1 nM) reduced the cross-sectional area of rat mesangial cells cultured on three-dimensional gels of collagen type I. ET-1 also caused complex rearrangements of F-actin microfilaments consistent with a motile response [22].
  • These findings indicate that FN is an important constituent of the glomerulus, and they are compatible with the assumption that, in the glomerulus, as in cultured cells, FN is involved in cell-to-cell (mesangial-mesangial, mesangial-endothelial) and cell-to-substrate (mesangial cell-mesangial matrix, epithelium-GBM, endothelium-GBM) attachment [23].
  • Activated macrophages trigger mesangial cells to express an array of inflammation-associated genes via activation of NF-kappaB and AP-1 [24].

Associations of Mesangial Cells with chemical compounds


Gene context of Mesangial Cells


Analytical, diagnostic and therapeutic context of Mesangial Cells


  1. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Shih, N.Y., Li, J., Karpitskii, V., Nguyen, A., Dustin, M.L., Kanagawa, O., Miner, J.H., Shaw, A.S. Science (1999) [Pubmed]
  2. Rat glomerular mesangial cells synthesize basic fibroblast growth factor. Release, upregulated synthesis, and mitogenicity in mesangial proliferative glomerulonephritis. Floege, J., Eng, E., Lindner, V., Alpers, C.E., Young, B.A., Reidy, M.A., Johnson, R.J. J. Clin. Invest. (1992) [Pubmed]
  3. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation. Johnson, R.J., Iida, H., Alpers, C.E., Majesky, M.W., Schwartz, S.M., Pritzi, P., Gordon, K., Gown, A.M. J. Clin. Invest. (1991) [Pubmed]
  4. Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. Koya, D., Jirousek, M.R., Lin, Y.W., Ishii, H., Kuboki, K., King, G.L. J. Clin. Invest. (1997) [Pubmed]
  5. Mesangial cell autoantigens in immunoglobulin A nephropathy and Henoch-Schönlein purpura. O'Donoghue, D.J., Darvill, A., Ballardie, F.W. J. Clin. Invest. (1991) [Pubmed]
  6. Glomerular mesangial cells: electrophysiology and regulation of contraction. Stockand, J.D., Sansom, S.C. Physiol. Rev. (1998) [Pubmed]
  7. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., Nilsson, M., Kurland, S., Törnell, J., Heath, J.K., Betsholtz, C. Cell (1996) [Pubmed]
  8. Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems. Ganz, M.B., Boyarsky, G., Sterzel, R.B., Boron, W.F. Nature (1989) [Pubmed]
  9. Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. Moura, I.C., Centelles, M.N., Arcos-Fajardo, M., Malheiros, D.M., Collawn, J.F., Cooper, M.D., Monteiro, R.C. J. Exp. Med. (2001) [Pubmed]
  10. Effect of graded hypoxia on the induction and function of inducible nitric oxide synthase in rat mesangial cells. Archer, S.L., Freude, K.A., Shultz, P.J. Circ. Res. (1995) [Pubmed]
  11. Fibronectin-induced increase in mesangial cell prostaglandin release. Effect of hyperglycemia and PKC inhibition. Dunlop, M., Keogh, R., Larkins, R.G. Diabetes (1993) [Pubmed]
  12. Platelet-activating factor biosynthesis by cultured mesangial cells is modulated by proteinase inhibitors. Biancone, L., Tetta, C., Turello, E., Montrucchio, G., Iorio, E.L., Servillo, L., Balestrieri, C., Camussi, G. J. Am. Soc. Nephrol. (1992) [Pubmed]
  13. The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad. Shimamura, H., Terada, Y., Okado, T., Tanaka, H., Inoshita, S., Sasaki, S. J. Am. Soc. Nephrol. (2003) [Pubmed]
  14. Production of an inhibitor of rat mesangial cell growth by the glomerulus and its alteration in puromycin nephrosis. Groggel, G.C., Hughes, M.L. J. Am. Soc. Nephrol. (1993) [Pubmed]
  15. Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism. Marsden, P.A., Ballermann, B.J. J. Exp. Med. (1990) [Pubmed]
  16. Autoimmune sequence of streptococcal M protein shared with the intermediate filament protein, vimentin. Kraus, W., Ohyama, K., Snyder, D.S., Beachey, E.H. J. Exp. Med. (1989) [Pubmed]
  17. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta. Ziyadeh, F.N., Sharma, K., Ericksen, M., Wolf, G. J. Clin. Invest. (1994) [Pubmed]
  18. Interleukin 1 alpha causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells. Gronich, J., Konieczkowski, M., Gelb, M.H., Nemenoff, R.A., Sedor, J.R. J. Clin. Invest. (1994) [Pubmed]
  19. Low density lipoprotein enhances the cellular action of arginine vasopressin in rat glomerular mesangial cells in culture. Ishikawa, S., Kawasumi, M., Okada, K., Saito, T. J. Clin. Invest. (1994) [Pubmed]
  20. Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells. Schlondorff, D., Satriano, J.A., Hagege, J., Perez, J., Baud, L. J. Clin. Invest. (1984) [Pubmed]
  21. Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy. Muraoka, K., Fujimoto, K., Sun, X., Yoshioka, K., Shimizu, K., Yagi, M., Bose, H., Miyazaki, I., Yamamoto, K. J. Clin. Invest. (1996) [Pubmed]
  22. Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation. Simonson, M.S., Dunn, M.J. J. Clin. Invest. (1990) [Pubmed]
  23. Fibronectin localization in the rat glomerulus. Courtoy, P.J., Kanwar, Y.S., Hynes, R.O., Farquhar, M.G. J. Cell Biol. (1980) [Pubmed]
  24. Priming of glomerular mesangial cells by activated macrophages causes blunted responses to proinflammatory stimuli. Hayakawa, K., Meng, Y., Hiramatsu, N., Kasai, A., Yamauchi, K., Yao, J., Kitamura, M. J. Immunol. (2006) [Pubmed]
  25. Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy. Skolnik, E.Y., Yang, Z., Makita, Z., Radoff, S., Kirstein, M., Vlassara, H. J. Exp. Med. (1991) [Pubmed]
  26. Reactive oxygen production by cultured rat glomerular mesangial cells during phagocytosis is associated with stimulation of lipoxygenase activity. Baud, L., Hagege, J., Sraer, J., Rondeau, E., Perez, J., Ardaillou, R. J. Exp. Med. (1983) [Pubmed]
  27. Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells. Owada, A., Tomita, K., Terada, Y., Sakamoto, H., Nonoguchi, H., Marumo, F. J. Clin. Invest. (1994) [Pubmed]
  28. Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells. Tetsuka, T., Daphna-Iken, D., Miller, B.W., Guan, Z., Baier, L.D., Morrison, A.R. J. Clin. Invest. (1996) [Pubmed]
  29. Association and direct activation of signal transducer and activator of transcription1alpha by platelet-derived growth factor receptor. Choudhury, G.G., Ghosh-Choudhury, N., Abboud, H.E. J. Clin. Invest. (1998) [Pubmed]
  30. Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens. Silver, B.J., Jaffer, F.E., Abboud, H.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  31. A novel biologic activity of thrombin: stimulation of monocyte chemotactic protein production. Grandaliano, G., Valente, A.J., Abboud, H.E. J. Exp. Med. (1994) [Pubmed]
  32. Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells. Kunz, D., Walker, G., Eberhardt, W., Messmer, U.K., Huwiler, A., Pfeilschifter, J. J. Clin. Invest. (1997) [Pubmed]
  33. Histamine modulates contraction and cyclic nucleotides in cultured rat mesangial cells. Differential effects mediated by histamine H1 and H2 receptors. Sedor, J.R., Abboud, H.E. J. Clin. Invest. (1985) [Pubmed]
  34. Production and physiological actions of anandamide in the vasculature of the rat kidney. Deutsch, D.G., Goligorsky, M.S., Schmid, P.C., Krebsbach, R.J., Schmid, H.H., Das, S.K., Dey, S.K., Arreaza, G., Thorup, C., Stefano, G., Moore, L.C. J. Clin. Invest. (1997) [Pubmed]
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