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Gene Review

PCDH7  -  protocadherin 7

Homo sapiens

Synonyms: BH-Pcdh, BHPCDH, Brain-heart protocadherin, PPP1R120, Protocadherin-7
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High impact information on PCDH7

  • BH-Pcdh has an extracellular domain consisting of seven repeats of the cadherin motif (EC 1 to 7) [1].
  • The BH-Pcdh gene was localized to human chromosome 4p15 [1].
  • There are three isoforms of BH-Pcdh, denoted -a, -b, and -c, which have different cytoplasmic tails and a 47-amino-acid deletion in the EC2-3 region of BH-Pcdh-c. While only a 9.0-kb message was detected in normal tissues, 4.5- and 9.0-kb mRNA species were seen in the human lung carcinoma cell line A549 [1].

Analytical, diagnostic and therapeutic context of PCDH7


  1. Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily. Yoshida, K., Yoshitomo-Nakagawa, K., Seki, N., Sasaki, M., Sugano, S. Genomics (1998) [Pubmed]
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