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Gene Review

UTP11L  -  UTP11-like, U3 small nucleolar...

Homo sapiens

Synonyms: CGI-94, CGI94, HDCMB12P, U3 snoRNA-associated protein 11, UTP11-like protein
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Psychiatry related information on UTP11L


High impact information on UTP11L

  • Here we describe second mitochondria-derived activator of caspases/Diablo as a new interacting protein of CGI-94 (comparative gene identification-94) which itself is probably involved in degenerative processes of Alzheimer's disease [2].
  • Immunohistochemical analyses reveal that CGI-94 is mainly expressed in neurons of the hippocampal formation and the cortex but not in the cerebellar nucleus [1].
  • Transfection experiments with CGI-94 as a green fluorescent protein (GFP)-fusion-protein show that this protein is translocated into the nucleus of the cell [1].

Biological context of UTP11L

  • Our findings that CGI-94 interacts with second mitochondria-derived activator of caspases/Diablo, inhibits nerve growth factor-induced neurite outgrowth and that its neuronal expression leads to cell death point to its pivotal role in the control of cellular survival [2].

Anatomical context of UTP11L

  • Here we describe a new protein, CGI-94, that is down-regulated at the mRNA level in the hippocampus of early stage AD brain [1].


  1. Characterizing CGI-94 (comparative gene identification-94) which is down-regulated in the hippocampus of early stage Alzheimer's disease brain. Heese, K., Nakayama, T., Hata, R., Masumura, M., Akatsu, H., Li, F., Nagai, Y., Yamamoto, T., Kosaka, K., Suemoto, T., Sawada, T. Eur. J. Neurosci. (2002) [Pubmed]
  2. Comparative gene identification-94--a pivotal regulator of apoptosis. Heese, K., Nagai, Y., Sawada, T. Neuroscience (2003) [Pubmed]
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