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Gene Review:

IGF2-AS - IGF2 antisense RNA

Homo sapiens

Synonyms: IGF2 antisense RNA 1, IGF2 antisense gene protein 1, IGF2-AS1, IGF2AS, PEG8, ...

Lee, H.J. et al., Okutsu, T. et al., Vu, T.H. et al.

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Disease relevance of IGF2AS

Interestingly, PEG8/IGF2AS and IGF2 were found to be overexpressed in Wilms' tumor samples, at levels over ten and a hundred times higher than that in normal kidney tissues neighboring the tumors, respectively [1].
This region consists of IGF2, insulin-like growth factor 2 antisense (IGF2AS), and the insulin gene, all important candidate genes for various diseases, including cancer, obesity, diabetes, and coronary disease [2].

High impact information on IGF2AS

IGF2-AS was expressed at levels comparable with IGF2 sense expression derived from promoters P1 and P2 in normal tissue and in breast, ovarian, and Wilms' tumor tissues [3].
We also analyzed linkage disequilibrium (LD) patterns and haplotypes using 36 high-frequency (> 5%)SNPs and found a well-defined LD block spanning about 13 kb that includes 8 kb of the IGF2AS gene, with two hot-spot regions flanking the LD block [2].

Other interactions of IGF2AS

Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors [1].

Analytical, diagnostic and therapeutic context of IGF2AS

IGF2-AS was detected as a 2.2 kb mRNA in Hep 3B cells by Northern blotting, and it encodes a putative 168 amino acid peptide [3].

References

Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors. Okutsu, T., Kuroiwa, Y., Kagitani, F., Kai, M., Aisaka, K., Tsutsumi, O., Kaneko, Y., Yokomori, K., Surani, M.A., Kohda, T., Kaneko-Ishino, T., Ishino, F. J. Biochem. (2000) [Pubmed]
Single-nucleotide polymorphisms and haplotype LD analysis of the 29-kb IGF2 region on chromosome 11p15.5 in the Korean population. Lee, H.J., Kim, K.J., Park, M.H., Kimm, K., Park, C., Oh, B., Lee, J.Y. Hum. Hered. (2005) [Pubmed]
Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. Vu, T.H., Chuyen, N.V., Li, T., Hoffman, A.R. Cancer Res. (2003) [Pubmed]

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