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Gene Review:

GMIP - GEM interacting protein

Homo sapiens

Synonyms: ARHGAP46, GEM-interacting protein

Tadokoro, K. et al., Salichs, A. et al., Vaidyanathan, G. et al.

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High impact information on GMIP

We found a significant association with MDD for one single nucleotide polymorphism (SNP) (-525G/A) located on the 5'-upstream region of the GMIP gene (p=0.039, odds ratio 1.66, 95% CI 1.05-2.69) and stronger evidence for association in a multimarker haplotype analysis (p=0.004) [1].
The Gem interacting protein (GMIP) gene is associated with major depressive disorder [1].
The Gem interacting protein, GMIP, is a novel Rho GTPase-activating protein known to play important roles in neurite growth and axonal guidance [1].
Comparison of the GMIPp values is made with two experimental hydrogen-bond scales: i) the hydrogen-bond basicity scale for N-heteroaromatics in carbon tetrachloride, and ii) the hydrogen-bond acidities for NH/OH donors and hydrogen-bond basicities of N/O acceptors determined in 1,1,1-trichloroethane [2].
For the preparation of this analogue, 3-guanidinomethyl-5-iodopyridine (GMIP; 9b), the silicon precursor 4 was synthesized starting from 5-bromonicotinic acid [3].

References

The Gem interacting protein (GMIP) gene is associated with major depressive disorder. Tadokoro, K., Hashimoto, R., Tatsumi, M., Kosuga, A., Kamijima, K., Kunugi, H. Neurogenetics (2005) [Pubmed]
Fast estimation of hydrogen-bonding donor and acceptor propensities: a GMIPp study. Salichs, A., López, M., Segarra, V., Orozco, M., Luque, F.J. J. Comput. Aided Mol. Des. (2002) [Pubmed]
Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine. Vaidyanathan, G., Zalutsky, M.R., DeGrado, T.R. Bioconjug. Chem. (1998) [Pubmed]

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