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Gene Review

YTHDF2  -  YTH N(6)-methyladenosine RNA binding...

Homo sapiens

Synonyms: CAHL, CLL-associated antigen KW-14, HGRG8, High-glucose-regulated protein 8, NY-REN-2, ...
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High impact information on YTHDF2

  • The locus, corresponding to a (TG)n microsatellite in the YTHDF2 gene, was identified by characterizing an "anonymous" marker detectable through inter-Alu fingerprinting, which previously evidenced an increased homozygosity in centenarians [1].
  • Remarkably, the same genotype was associated with increased YTHDF2 messenger RNA levels in immortalized lymphocytes [1].
  • Finally, YTHDF2 messenger RNA resulted to be mainly expressed in testis and placenta [1].


  1. A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. Cardelli, M., Marchegiani, F., Cavallone, L., Olivieri, F., Giovagnetti, S., Mugianesi, E., Moresi, R., Lisa, R., Franceschi, C. J. Gerontol. A Biol. Sci. Med. Sci. (2006) [Pubmed]
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