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MeSH Review

Aged, 80 and over

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Disease relevance of Aged, 80 and over


Psychiatry related information on Aged, 80 and over

  • Senile dementia with tangles is suggested to be a variant of Alzheimer disease occurring in the oldest-old, but its nosological position within aging disorders of the brain is still controversy [6].
  • In agreement with previous studies in very old cohorts, they also suggest that amyloid deposition is not related to the early stages of the dementia process in the oldest old [7].
  • Alzheimer disease shortened survival time most dramatically in younger participants, but vascular dementia posed a greater mortality risk among the oldest old [8].
  • Rates of cognitive impairment in a representative population of the oldest old (aged 84 to 90) were examined using two indicators: The Global Deterioration Scale (GDS), and a Cognitive Rating (CR) derived from performance on five neuropsychological tests [9].
  • The study was designed to assess the antioxidant defense mechanisms, either enzymatic or non-enzymatic, in a group of sixteen centenarians (one male and fifteen female subjects aged 101 to 105 years) living in the Upper Silesia district (Poland) in order to evaluate the potential role of antioxidant defenses in human longevity [10].

High impact information on Aged, 80 and over

  • We find that the epsilon 4 allele of APOE, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p < 0.001), while the frequency of the epsilon 2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p < 0.01) [11].
  • The centenarian Golgi apparatus [12].
  • Total cholesterol and risk of mortality in the oldest old [13].
  • We have therefore investigated the MTP "risk" haplotype in our own collection of 1,589 German nonagenarians, centenarians, and appropriately matched controls [14].
  • p53 variants predisposing to cancer are present in healthy centenarians [15].

Chemical compound and disease context of Aged, 80 and over


Biological context of Aged, 80 and over


Anatomical context of Aged, 80 and over


Associations of Aged, 80 and over with chemical compounds

  • Accordingly, we measured Lp(a) levels as well as total, LDL, and HDL cholesterol (CT), and triglycerides (TG) in sera from 75 healthy centenarians, 114 randomly selected subjects under 65 years, 73 randomly selected elderly people, and 30 healthy selected elderly people [30].
  • The circadian profile of serum cortisol was clearly flattened in old subjects, due to the selective increase in the cortisol nocturnal levels, particularly evident in demented subjects; on the other hand, the morning serum cortisol levels were not significantly different among centenarians, young and old controls [16].
  • Percutaneous coronary intervention in octogenarians and the safety of glycoprotein IIb/IIIa inhibitors [31].
  • Centenarians had also a whole body glucose disposal (WBGD) greater than that in aged subjects, but similar to that in adults [32].
  • The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds [33].

Gene context of Aged, 80 and over

  • Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians [34].
  • In this study we examined 230 Japanese centenarians and 180 healthy younger controls and looked at the SHC1 locus as a candidate region that may be associated with longevity [35].
  • Although heterozygous CETP deficiency and the B2 allele of the Taq1B polymorphism was consistently associated with higher HDL-C concentrations both in centenarians and controls, the allelic frequencies of those polymorphisms did not differ between the two groups [36].
  • Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer's disease patients and centenarians [37].
  • CONCLUSION: Low-grade activation of the TNF system could limit the increase in muscle strength after resistance training in the oldest old [38].

Analytical, diagnostic and therapeutic context of Aged, 80 and over


  1. The A677V MTHFR allele is not associated with carotid atherosclerosis in octogenarians. Zuliani, G., Volpato, S., Mecocci, P., Cherubini, A. Stroke (2000) [Pubmed]
  2. Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians. Mannucci, P.M., Mari, D., Merati, G., Peyvandi, F., Tagliabue, L., Sacchi, E., Taioli, E., Sansoni, P., Bertolini, S., Franceschi, C. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  3. Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease. Tanaka, M., Fuku, N., Takeyasu, T., Guo, L.J., Hirose, R., Kurata, M., Borgeld, H.J., Yamada, Y., Maruyama, W., Arai, Y., Hirose, N., Oshida, Y., Sato, Y., Hattori, N., Mizuno, Y., Iwata, S., Yagi, K. J. Neurosci. Res. (2002) [Pubmed]
  4. Midterm outcome of endovascular abdominal aortic aneurysm repair in octogenarians: a single institution's experience. Biebl, M., Lau, L.L., Hakaim, A.G., Oldenburg, W.A., Klocker, J., Neuhauser, B., McKinney, J.M., Paz-Fumagalli, R. J. Vasc. Surg. (2004) [Pubmed]
  5. Deciding on anticoagulating the oldest old with atrial fibrillation: insights from cost-effectiveness analysis. Desbiens, N.A. Journal of the American Geriatrics Society. (2002) [Pubmed]
  6. Senile dementia with tangles (tangle predominant form of senile dementia). Jellinger, K.A., Bancher, C. Brain Pathol. (1998) [Pubmed]
  7. Mild amyloid pathology in the primary visual system of nonagenarians and centenarians. Leuba, G., Saini, K., Zimmermann, V., Giannakopoulos, P., Bouras, C. Dementia and geriatric cognitive disorders. (2001) [Pubmed]
  8. Dementia: the leading predictor of death in a defined elderly population: the Cache County Study. Tschanz, J.T., Corcoran, C., Skoog, I., Khachaturian, A.S., Herrick, J., Hayden, K.M., Welsh-Bohmer, K.A., Calvert, T., Norton, M.C., Zandi, P., Breitner, J.C. Neurology (2004) [Pubmed]
  9. Dementia and cognitive impairment in the oldest old: a comparison of two rating methods. Johansson, B., Zarit, S.H. International psychogeriatrics / IPA. (1991) [Pubmed]
  10. Antioxidant defense in centenarians (a preliminary study). Kłapcińska, B., Derejczyk, J., Wieczorowska-Tobis, K., Sobczak, A., Sadowska-Krepa, E., Danch, A. Acta Biochim. Pol. (2000) [Pubmed]
  11. Genetic associations with human longevity at the APOE and ACE loci. Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., Cohen, D. Nat. Genet. (1994) [Pubmed]
  12. The centenarian Golgi apparatus. Mazzarello, P., Bentivoglio, M. Nature (1998) [Pubmed]
  13. Total cholesterol and risk of mortality in the oldest old. Weverling-Rijnsburger, A.W., Blauw, G.J., Lagaay, A.M., Knook, D.L., Meinders, A.E., Westendorp, R.G. Lancet (1997) [Pubmed]
  14. No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. Nebel, A., Croucher, P.J., Stiegeler, R., Nikolaus, S., Krawczak, M., Schreiber, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  15. p53 variants predisposing to cancer are present in healthy centenarians. Bonafè, M., Olivieri, F., Mari, D., Baggio, G., Mattace, R., Sansoni, P., De Benedictis, G., De Luca, M., Bertolini, S., Barbi, C., Monti, D., Franceschi, C. Am. J. Hum. Genet. (1999) [Pubmed]
  16. Age-related changes of the adrenal secretory pattern: possible role in pathological brain aging. Ferrari, E., Casarotti, D., Muzzoni, B., Albertelli, N., Cravello, L., Fioravanti, M., Solerte, S.B., Magri, F. Brain Res. Brain Res. Rev. (2001) [Pubmed]
  17. Vipoma: effective treatment with octreotide in the oldest old. Schoevaerdts, D., Favet, L., Zekry, D., Sieber, C.C., Michel, J.P. Journal of the American Geriatrics Society. (2001) [Pubmed]
  18. Age-related differences in the metabolism of sulphite to sulphate and in the identification of sulphur trioxide radical in human polymorphonuclear leukocytes. Constantin, D., Bini, A., Meletti, E., Moldeus, P., Monti, D., Tomasi, A. Mech. Ageing Dev. (1996) [Pubmed]
  19. Ibutilide in rapid conversion of atrial flutter in octogenarians. Antonicelli, R., Testarmata, P., Recanatini, A. Drugs & aging. (2002) [Pubmed]
  20. Spontaneous recovery from a spinal epidural hematoma with atypical presentation in a nonagenarian. Schwarz, S.K., Wong, C.L., McDonald, W.N. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2004) [Pubmed]
  21. A model for antagonistic pleiotropic gene action for mortality and advanced age. Toupance, B., Godelle, B., Gouyon, P.H., Schächter, F. Am. J. Hum. Genet. (1998) [Pubmed]
  22. Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: studies on centenarians. Pinti, M., Troiano, L., Nasi, M., Moretti, L., Monterastelli, E., Mazzacani, A., Mussi, C., Ventura, P., Olivieri, F., Franceschi, C., Salvioli, G., Cossarizza, A. Cell Death Differ. (2002) [Pubmed]
  23. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. Hadrup, S.R., Strindhall, J., Køllgaard, T., Seremet, T., Johansson, B., Pawelec, G., thor Straten, P., Wikby, A. J. Immunol. (2006) [Pubmed]
  24. Cardiac surgery in octogenarians; peri-operative outcome and long-term results. Kolh, P., Kerzmann, A., Lahaye, L., Gerard, P., Limet, R. Eur. Heart J. (2001) [Pubmed]
  25. Elevated plasma activator inhibitor 1 is not related to insulin resistance and to gene polymorphism in healthy centenarians. Rizzo, M.R., Ragno, E., Barbieri, M., De Lucia, D., Manzella, D., Tagliamonte, M.R., Colaizzo, D., Margaglione, M., Paolisso, G. Atherosclerosis (2002) [Pubmed]
  26. Mean arterial blood pressure and serum levels of the molar ratio of insulin-like growth factor-1 to its binding protein-3 in healthy centenarians. Paolisso, G., Tagliamonte, M.R., Rizzo, M.R., Rotondi, M., Gualdiero, P., Gambardella, A., Barbieri, M., Carella, C., Giugliano, D., Varricchio, M. J. Hypertens. (1999) [Pubmed]
  27. Chemokine production by natural killer cells from nonagenarians. Mariani, E., Meneghetti, A., Neri, S., Ravaglia, G., Forti, P., Cattini, L., Facchini, A. Eur. J. Immunol. (2002) [Pubmed]
  28. Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: evidence for sparing of the entorhinal cortex and CA1 field. von Gunten, A., Kövari, E., Rivara, C.B., Bouras, C., Hof, P.R., Giannakopoulos, P. Exp. Neurol. (2005) [Pubmed]
  29. RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects. Mariani, E., Pulsatelli, L., Neri, S., Dolzani, P., Meneghetti, A., Silvestri, T., Ravaglia, G., Forti, P., Cattini, L., Facchini, A. Exp. Gerontol. (2002) [Pubmed]
  30. Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors. Baggio, G., Donazzan, S., Monti, D., Mari, D., Martini, S., Gabelli, C., Dalla Vestra, M., Previato, L., Guido, M., Pigozzo, S., Cortella, I., Crepaldi, G., Franceschi, C. FASEB J. (1998) [Pubmed]
  31. Percutaneous coronary intervention in octogenarians and the safety of glycoprotein IIb/IIIa inhibitors. Ragosta, M. J. Am. Coll. Cardiol. (2003) [Pubmed]
  32. Serum levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in healthy centenarians: relationship with plasma leptin and lipid concentrations, insulin action, and cognitive function. Paolisso, G., Ammendola, S., Del Buono, A., Gambardella, A., Riondino, M., Tagliamonte, M.R., Rizzo, M.R., Carella, C., Varricchio, M. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  33. The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds. Ravaglia, G., Forti, P., Maioli, F., Boschi, F., Bernardi, M., Pratelli, L., Pizzoferrato, A., Gasbarrini, G. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  34. Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. Bonafè, M., Marchegiani, F., Cardelli, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Pieri, C., Marra, M., Antonicelli, R., Troiano, L., Gueresi, P., Passeri, G., Berardelli, M., Paolisso, G., Barbieri, M., Tesei, S., Lisa, R., De Benedictis, G., Franceschi, C. Eur. J. Hum. Genet. (2002) [Pubmed]
  35. Association analysis of the SHC1 gene locus with longevity in the Japanese population. Kamei, H., Adati, N., Arai, Y., Yamamura, K., Takayama, M., Nakazawa, S., Ebihara, Y., Gondo, Y., Akechi, M., Noguchi, T., Hirose, N., Sakaki, Y., Kojima, T. J. Mol. Med. (2003) [Pubmed]
  36. Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity. Arai, Y., Hirose, N., Yamamura, K., Nakazawa, S., Shimizu, K., Takayama, M., Ebihara, Y., Homma, S., Gondo, Y., Masui, Y., Inagaki, H. J. Mol. Med. (2003) [Pubmed]
  37. Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer's disease patients and centenarians. Panza, F., Solfrizzi, V., Colacicco, A.M., Basile, A.M., D'Introno, A., Capurso, C., Sabba, M., Capurso, S., Capurso, A. Neuroreport (2003) [Pubmed]
  38. Muscle strength after resistance training is inversely correlated with baseline levels of soluble tumor necrosis factor receptors in the oldest old. Bruunsgaard, H., Bjerregaard, E., Schroll, M., Pedersen, B.K. Journal of the American Geriatrics Society. (2004) [Pubmed]
  39. Association between the MLH1 gene and longevity. Kim, D.J., Yi, S.M., Lee, S.Y., Kang, H.S., Choi, Y.H., Song, Y.W., Park, S.C. Hum. Genet. (2006) [Pubmed]
  40. Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study. Riphaus, A., Stergiou, N., Wehrmann, T. Am. J. Gastroenterol. (2005) [Pubmed]
  41. Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians. Muiras, M.L., Müller, M., Schächter, F., Bürkle, A. J. Mol. Med. (1998) [Pubmed]
  42. Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity? Gangemi, S., Basile, G., Merendino, R.A., Minciullo, P.L., Novick, D., Rubinstein, M., Dinarello, C.A., Lo Balbo, C., Franceschi, C., Basili, S., D' Urbano, E., Daví, G., Nicita-Mauro, V., Romano, M. Exp. Gerontol. (2003) [Pubmed]
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