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Gene Review

LCMT1  -  leucine carboxyl methyltransferase 1

Homo sapiens

Synonyms: CGI-68, LCMT, Leucine carboxyl methyltransferase 1, PPMT1, Protein-leucine O-methyltransferase
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High impact information on LCMT1

  • We propose that the deregulation of PPMT and PP2A methylation/demethylation cycles contributes to AD pathogenesis, by inducing changes in PP2A heteromultimeric composition and substrate specificity [1].
  • Notably, the carboxyl methylation of PP2A catalytic subunit (PP2A(C)) is critically required for ABalphaC holoenzyme assembly, and catalyzed by a specific methyltransferase (PPMT) [1].

Biological context of LCMT1

  • Immunoblotting analyses revealed that PPMT protein expression and PP2A(C) methylation levels were quantitatively decreased in AD-affected brain regions [1].

Anatomical context of LCMT1

  • The GTPgammaS-dependent carboxyl methylation of endogenous substrates in liver membranes was decreased by 35% in the presence of Chaps, suggesting that PPMT was not the predominant methyltransferase involved in the methylation stimulated by GTPgammaS in liver membranes [2].


  1. Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. Sontag, E., Hladik, C., Montgomery, L., Luangpirom, A., Mudrak, I., Ogris, E., White, C.L. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  2. Guanosine 5'-(3-O-Thio)triphosphate stimulates protein carboxyl methylation in cell membranes. Desrosiers, R.R., Béliveau, R. Arch. Biochem. Biophys. (1999) [Pubmed]
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