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Gene Review:

PDGFRL - platelet-derived growth factor receptor-like

Homo sapiens

Synonyms: PDGF receptor beta-like tumor suppressor, PDGFR-like protein, PDGRL, PRLTS, Platelet-derived growth factor receptor-like protein

Komiya, A. et al., Kahng, Y.S. et al., An, Q. et al., Fujiwara, Y. et al.

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Disease relevance of PDGFRL

These findings indicate that inactivation of the PRLTS gene may play a significant role in development of some carcinomas [1].
PRLTS gene alterations in human prostate cancer [2].
Our data indicated a possible correlation between specific TSG(s) and either histological type of lung cancer, and more attention should be paid to the PRLTS gene, which might play an important role in the development of ADC [3].

High impact information on PDGFRL

Although loss of heterozygosity at the PRLTS gene locus is a relatively common abnormality, mutation of this gene is rare in prostate cancer [2].
One cancer-death patient had a missense mutation, ACG-->ATG (Thr-->Met) at codon 64 in metastatic tumor tissues of pelvic lymph node and liver, and these tissues showed loss of the homologous allele, indicating that "two-hit" mutation of the PRLTS gene had occurred in this case [2].
Platelet-derived growth factor-receptor beta-like tumor suppressor gene (PRLTS) and deletion in liver cancer-1 tumor suppressor gene are located at 8p21.3-p22 [4].
D8S261, located adjacent to PRLTS, showed most frequent LOH: 28.6% in dysplastic nodule and 40.0% in hepatocellular carcinoma [4].

References

Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. Fujiwara, Y., Ohata, H., Kuroki, T., Koyama, K., Tsuchiya, E., Monden, M., Nakamura, Y. Oncogene (1995) [Pubmed]
PRLTS gene alterations in human prostate cancer. Komiya, A., Suzuki, H., Ueda, T., Aida, S., Ito, N., Shiraishi, T., Yatani, R., Emi, M., Yasuda, K., Shimazaki, J., Ito, H. Jpn. J. Cancer Res. (1997) [Pubmed]
Deletion of tumor suppressor genes in Chinese non-small cell lung cancer. An, Q., Liu, Y., Gao, Y., Huang, J., Fong, X., Liu, L., Zhang, D., Zhang, J., Cheng, S. Cancer Lett. (2002) [Pubmed]
Loss of heterozygosity of chromosome 8p and 11p in the dysplastic nodule and hepatocellular carcinoma. Kahng, Y.S., Lee, Y.S., Kim, B.K., Park, W.S., Lee, J.Y., Kang, C.S. J. Gastroenterol. Hepatol. (2003) [Pubmed]

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