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Gene Review:

LIPT1 - lipoyltransferase 1

Homo sapiens

Synonyms: Lipoate biosynthesis protein, Lipoate-protein ligase, Lipoyl ligase, Lipoyltransferase 1, mitochondrial, MGC12290, ...

Fujiwara, K. et al., Gueguen, V. et al.

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Disease relevance of LIPT1

Predicted amino acid sequence of the protein shares 88 and 31% identity with bovine lipoyltransferase and Escherichia coli lipoate-protein ligase A, respectively [1].

High impact information on LIPT1

We showed that Val(62) and Ala(64), surrounding the lipoyl-lysine, play an important role in the molecular events that govern the reaction between P and H protein but do not intervene in the recognition of the binding site of lipoic acid by lipoyl ligase [2].
The human lipoyltransferase gene was localized to chromosome band 2q11.2 by fluorescence in situ hybridization [1].
The human lipoyltransferase gene is a single copy gene composed of four exons and three introns spanning approximately 8 kb of genomic DNA [1].

Analytical, diagnostic and therapeutic context of LIPT1

Molecular cloning, structural characterization and chromosomal localization of human lipoyltransferase gene [1].

References

Molecular cloning, structural characterization and chromosomal localization of human lipoyltransferase gene. Fujiwara, K., Suzuki, M., Okumachi, Y., Okamura-Ikeda, K., Fujiwara, T., Takahashi, E., Motokawa, Y. Eur. J. Biochem. (1999) [Pubmed]
Structural and functional characterization of H protein mutants of the glycine decarboxylase complex. Gueguen, V., Macherel, D., Neuburger, M., Pierre, C.S., Jaquinod, M., Gans, P., Douce, R., Bourguignon, J. J. Biol. Chem. (1999) [Pubmed]

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AgaP_AGAP012186	Anopheles gambiae str. PEST
LIPT1	Bos taurus
C45G3.3	Caenorhabditis elegans
LIPT1	Canis lupus familiaris
lipt1	Danio rerio
CG44243	Drosophila melanogaster
LIPT1	Gallus gallus
LIPT1	Macaca mulatta
MGG_03282	Magnaporthe oryzae 70-15
Lipt1	Mus musculus
NCU05421	Neurospora crassa OR74A
LIPT1	Pan troglodytes
Lipt1	Rattus norvegicus
aim22	Schizosaccharomyces pombe 972h-
lipt1	Xenopus (Silurana) tropicalis

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