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Gene Review

HPD  -  4-hydroxyphenylpyruvate dioxygenase

Bos taurus

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High impact information on HPD

  • We have characterized mutations in the HPD motif of the synaptic vesicle protein cysteine-string protein (Csp) [1].
  • Thus, the HPD motif of Csp is required for binding to Hsc70 [1].
  • The conserved tripeptide, HPD, present in all J domains has been shown to be important for the interaction between yeast and bacterial DnaJ/Hsp70 protein pairs [1].
  • Cultured cells showed dose dependent sensitivity to both unactivated HPD and phycocyanin with minimal cytotoxicity (less than 20%) at concentrations below 0.5 and 50 micrograms/ml, respectively [2].


  1. The molecular chaperone function of the secretory vesicle cysteine string proteins. Chamberlain, L.H., Burgoyne, R.D. J. Biol. Chem. (1997) [Pubmed]
  2. Bovine coronary artery endothelium: culture, characterization, angiogenesis and sensitivity to laser photodynamic treatment modalities. Morcos, N.C., Zaldivar, F., lo Hsueh, M., Henry, W.L. Journal of clinical & laboratory immunology. (1991) [Pubmed]
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