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Gene Review

HSPA1A  -  heat shock 70kDa protein 1A

Bos taurus

Synonyms: HSP70-1, HSPA1
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Disease relevance of HSPA1A


High impact information on HSPA1A

  • We propose a mechanism for the regulation of eukaryotic Hsc70 that is distinct from that of bacterial Hsp70 [4].
  • In conjunction with hsp70, DnaJ proteins catalyse protein folding, protein transport across membranes and the selective disruption of protein-protein interactions [5].
  • Here we show that HSP 70 binds to the surface of antigen presenting cells by a mechanism with the characteristics of a saturable receptor system [6].
  • Neither S-nitrosation of caspase-3 nor induction of Hsp70 appeared to play a significant role in the antiapoptotic mechanism of *NO in oxLDL-induced endothelial apoptosis [7].
  • Hsp70 is a multifunctional molecular chaperone whose interactions with protein substrates are regulated by ATP hydrolysis and ADP-ATP exchange [8].

Chemical compound and disease context of HSPA1A


Biological context of HSPA1A


Anatomical context of HSPA1A

  • These carbamylated proteins were shown to have similar focusing mobilities to the Hsp70 isoforms isolated from bovine skeletal muscle [15].
  • The 70-kDa heat-shock protein (Hsp70) has been cloned and sequenced from bovine cardiac muscle [1].
  • In the presence of ATP, bovine brain hsp70 has been shown to remove clathrin from bovine brain clathrin-coated vesicles in a rapid stoichiometric initial burst followed by slow steady-state uncoating [16].
  • Recently it has been demonstrated that heat shock protein 70 (hsp70) is induced in pancreatic islet cells during prolonged exposure to interleukin 1 beta (IL-1 beta) [17].
  • The ability of hsp70 isoenzymes from wild-type and mutant yeast strains to uncoat bovine brain coated vesicles was analyzed and compared with that of the brain uncoating ATPase [18].

Associations of HSPA1A with chemical compounds

  • During the reaction, Hsp70 formed an acid-labile autophosphorylated intermediate, and nucleoside diphosphate-dependent dephosphorylation of the latter then occurred [8].
  • These properties of Hsp70 are not identical but similar to those of NDP kinase, but are not similar to those of adenylate kinase and ATP synthase [8].
  • To assess the role for hsp70 in isolated islets exposed to IL-1 beta, hsp70 was purified and introduced into cells of isolated rat pancreatic islets via the liposome technique [17].
  • Our research with rats demonstrates for the first time that administration of exogeneous Hsp70 before and after LPS challenges can reduce mortality rates and modify several parameters of hemostasis and hemodynamics [10].
  • Western blots determined the relative accumulation of Hsp70 in urea soluble lens fractions [11].

Regulatory relationships of HSPA1A

  • In Dex-treated cultures subjected to heat shock, hsc70 antisense RNA blocked the induction of hsp70, indicating that newly synthesized RNA was targeted effectively before it became translationally active [19].

Other interactions of HSPA1A


Analytical, diagnostic and therapeutic context of HSPA1A


  1. Molecular cloning of bovine cardiac muscle heat-shock protein 70 kDa and its phosphorylation by cAMP-dependent protein kinase in vitro. Lakshmikuttyamma, A., Selvakumar, P., Anderson, D.H., Datla, R.S., Sharma, R.K. Biochemistry (2004) [Pubmed]
  2. Deletion of one of the duplicated Hsp70 genes causes hereditary myopathy of diaphragmatic muscles in Holstein-Friesian cattle. Sugimoto, M., Furuoka, H., Sugimoto, Y. Anim. Genet. (2003) [Pubmed]
  3. Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia. Knowlton, A.A., Brecher, P., Apstein, C.S. J. Clin. Invest. (1991) [Pubmed]
  4. Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle. Höhfeld, J., Minami, Y., Hartl, F.U. Cell (1995) [Pubmed]
  5. Role of auxilin in uncoating clathrin-coated vesicles. Ungewickell, E., Ungewickell, H., Holstein, S.E., Lindner, R., Prasad, K., Barouch, W., Martin, B., Greene, L.E., Eisenberg, E. Nature (1995) [Pubmed]
  6. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. Castellino, F., Boucher, P.E., Eichelberg, K., Mayhew, M., Rothman, J.E., Houghton, A.N., Germain, R.N. J. Exp. Med. (2000) [Pubmed]
  7. Inhibition of oxidized low-density lipoprotein-induced apoptosis in endothelial cells by nitric oxide. Peroxyl radical scavenging as an antiapoptotic mechanism. Kotamraju, S., Hogg, N., Joseph, J., Keefer, L.K., Kalyanaraman, B. J. Biol. Chem. (2001) [Pubmed]
  8. Intrinsic ADP-ATP exchange activity is a novel function of the molecular chaperone, Hsp70. Hiromura, M., Yano, M., Mori, H., Inoue, M., Kido, H. J. Biol. Chem. (1998) [Pubmed]
  9. The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. Skinner, M.A., Wedlock, D.N., de Lisle, G.W., Cooke, M.M., Tascon, R.E., Ferraz, J.C., Lowrie, D.B., Vordermeier, H.M., Hewinson, R.G., Buddle, B.M. Infect. Immun. (2005) [Pubmed]
  10. Exogenous heat shock protein 70 mediates sepsis manifestations and decreases the mortality rate in rats. Kustanova, G.A., Murashev, A.N., Karpov, V.L., Margulis, B.A., Guzhova, I.V., Prokhorenko, I.R., Grachev, S.V., Evgen'ev, M.B. Cell Stress Chaperones (2006) [Pubmed]
  11. Hsp70 in bovine lenses during temperature stress. Banh, A., Vijayan, M.M., Sivak, J.G. Mol. Vis. (2003) [Pubmed]
  12. A subunit gIV vaccine, produced by transfected mammalian cells in culture, induces mucosal immunity against bovine herpesvirus-1 in cattle. van Drunen Littel-van den Hurk, S., Van Donkersgoed, J., Kowalski, J., van den Hurk, J.V., Harland, R., Babiuk, L.A., Zamb, T.J. Vaccine (1994) [Pubmed]
  13. Changes associated with tyrosine phosphorylation during short-term hypoxia in retinal microvascular endothelial cells in vitro. Koroma, B.M., de Juan, E. J. Cell. Biochem. (1995) [Pubmed]
  14. Chromosomal localization of HSP70 genes in cattle. Gallagher, D.S., Grosz, M.D., Womack, J.E., Skow, L.C. Mamm. Genome (1993) [Pubmed]
  15. Chemical modifications of a recombinant bovine stress-inducible 70 kDa heat-shock protein (Hsp70) mimics Hsp70 isoforms from tissues. Gutierrez, J.A., Guerriero, V. Biochem. J. (1995) [Pubmed]
  16. ATPase activity associated with the uncoating of clathrin baskets by Hsp70. Barouch, W., Prasad, K., Greene, L.E., Eisenberg, E. J. Biol. Chem. (1994) [Pubmed]
  17. Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function. Margulis, B.A., Sandler, S., Eizirik, D.L., Welsh, N., Welsh, M. Diabetes (1991) [Pubmed]
  18. Uncoating of coated vesicles by yeast hsp70 proteins. Gao, B.C., Biosca, J., Craig, E.A., Greene, L.E., Eisenberg, E. J. Biol. Chem. (1991) [Pubmed]
  19. Effects of dexamethasone, heat shock, and serum responses on the inhibition of Hsc70 synthesis by antisense RNA in NIH 3T3 cells. Li, T., Hightower, L.E. J. Cell. Physiol. (1995) [Pubmed]
  20. Molecular characterisation of a hsp70 gene from the filarial parasite Setaria digitata. Jayasena, S.M., Chandrasekharan, N.V., Karunanayake, E.H. Int. J. Parasitol. (1999) [Pubmed]
  21. Purification of a new clathrin assembly protein from bovine brain coated vesicles and its identification as myelin basic protein. Prasad, K., Barouch, W., Martin, B.M., Greene, L.E., Eisenberg, E. J. Biol. Chem. (1995) [Pubmed]
  22. Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73-kDa heat shock cognate protein. Terlecky, S.R., Chiang, H.L., Olson, T.S., Dice, J.F. J. Biol. Chem. (1992) [Pubmed]
  23. Subarachnoid injections of lysed blood induce the hsp70 stress gene and produce DNA fragmentation in focal areas of the rat brain. Matz, P., Weinstein, P., States, B., Honkaniemi, J., Sharp, F.R. Stroke (1996) [Pubmed]
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