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Gene Review

PDS1  -  4-hydroxyphenylpyruvate dioxygenase

Arabidopsis thaliana

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Disease relevance of PDS1

  • We investigated the biochemical characteristics of this 4HPPD by overproducing the recombinant protein in Escherichia coli JM105 [1].
  • The subcellular localization of the recombinant 4HPPD in chlorophyllous tissues was examined by overexpressing its complete coding sequence in transgenic tobacco (Nicotiana tabacum), using Agrobacterium tumefaciens transformation [1].

High impact information on PDS1


Chemical compound and disease context of PDS1


Anatomical context of PDS1

  • These analyses clearly revealed that 4HPPD was confined to the cytosol compartment, not targeted to the chloroplast [1].

Associations of PDS1 with chemical compounds


Analytical, diagnostic and therapeutic context of PDS1

  • First, the amount of genomic DNA in the extracts, obtained from an individual A. thaliana transformant, was accurately determined by the 1st competitive PCR using a known single copy gene, 4HPPD (4-hydroxyphenylpyruvate dioxygenase), as a target [8].


  1. Characterization and subcellular compartmentation of recombinant 4-hydroxyphenylpyruvate dioxygenase from Arabidopsis in transgenic tobacco. Garcia, I., Rodgers, M., Pepin, R., Hsieh, T.F., Matringe, M. Plant Physiol. (1999) [Pubmed]
  2. Mutations in the Arabidopsis gene IMMUTANS cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation. Carol, P., Stevenson, D., Bisanz, C., Breitenbach, J., Sandmann, G., Mache, R., Coupland, G., Kuntz, M. Plant Cell (1999) [Pubmed]
  3. Genetic dissection of carotenoid synthesis in arabidopsis defines plastoquinone as an essential component of phytoene desaturation. Norris, S.R., Barrette, T.R., DellaPenna, D. Plant Cell (1995) [Pubmed]
  4. Complementation of the Arabidopsis pds1 mutation with the gene encoding p-hydroxyphenylpyruvate dioxygenase. Norris, S.R., Shen, X., DellaPenna, D. Plant Physiol. (1998) [Pubmed]
  5. The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase. Fritze, I.M., Linden, L., Freigang, J., Auerbach, G., Huber, R., Steinbacher, S. Plant Physiol. (2004) [Pubmed]
  6. The Arabidopsis immutans mutation affects plastid differentiation and the morphogenesis of white and green sectors in variegated plants. Aluru, M.R., Bae, H., Wu, D., Rodermel, S.R. Plant Physiol. (2001) [Pubmed]
  7. Engineering plant shikimate pathway for production of tocotrienol and improving herbicide resistance. Rippert, P., Scimemi, C., Dubald, M., Matringe, M. Plant Physiol. (2004) [Pubmed]
  8. Determination of gene copy number and genotype of transgenic Arabidopsis thaliana by competitive PCR. Honda, M., Muramoto, Y., Kuzuguchi, T., Sawano, S., Machida, M., Koyama, H. J. Exp. Bot. (2002) [Pubmed]
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