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Gene Review

CAB39  -  calcium binding protein 39

Homo sapiens

Synonyms: CGI-66, Calcium-binding protein 39, MO25, MO25alpha, Protein Mo25
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High impact information on CAB39

  • Interestingly, 12 of these mutants failed to interact with STRAD-MO25 [1].
  • In vivo, LKB1 forms a complex with STRAD, an inactive pseudokinase, and MO25, an armadillo repeat scaffolding-like protein [1].
  • The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction [2].

Biological context of CAB39

  • Human MO25 is a cofactor of LKB1, a conserved protein kinase with roles in cell polarity in nematodes, flies and mammalian cells [3].

Physical interactions of CAB39

  • MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity [4].


  1. Analysis of the LKB1-STRAD-MO25 complex. Boudeau, J., Scott, J.W., Resta, N., Deak, M., Kieloch, A., Komander, D., Hardie, D.G., Prescott, A.R., van Aalten, D.M., Alessi, D.R. J. Cell. Sci. (2004) [Pubmed]
  2. Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25. Ellingson, W.J., Chesser, D.G., Winder, W.W. Am. J. Physiol. Endocrinol. Metab. (2007) [Pubmed]
  3. The fission yeast MO25 protein functions in polar growth and cell separation. Mendoza, M., Redemann, S., Brunner, D. Eur. J. Cell Biol. (2005) [Pubmed]
  4. Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. Milburn, C.C., Boudeau, J., Deak, M., Alessi, D.R., van Aalten, D.M. Nat. Struct. Mol. Biol. (2004) [Pubmed]
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