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Gene Review

STRADA  -  STE20-related kinase adaptor alpha

Homo sapiens

Synonyms: LYK5, NY-BR-96, PMSE, STE20-related adapter protein, STE20-related kinase adapter protein alpha, ...
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Disease relevance of LYK5


High impact information on LYK5

  • We have now constructed intestinal epithelial cell lines in which inducible STRAD activates LKB1 [3].
  • Interestingly, 12 of these mutants failed to interact with STRAD-MO25 [4].
  • Specific LOH of the STRAD marker was found in four of 29 informative cases [2].
  • CONCLUSIONS: Despite the frequent occurrence of LOH in the STRAD region, these results indicate that inactivation of the STRAD gene is not essential in the sporadic adenocarcinomas studied, although it is possible that STRAD may be inactivated in different ways [2].
  • For these patients all exons and exon-intron boundaries of the STRAD gene were sequenced, but no somatic mutations were identified [2].

Biological context of LYK5

  • Furthermore, no germline STRAD mutations were found in 10 patients with PJS and family members without LKB1 germline mutation [2].
  • A complex with the STRAD alpha peptide reveals a hydrophobic pocket that is involved in a unique and specific interaction with the Trp-Glu-Phe motif, further supported by mutagenesis studies [5].

Physical interactions of LYK5

  • MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity [5].

Regulatory relationships of LYK5

  • Our results imply that STRAD plays a key role in regulating the tumour suppressor activities of LKB1 [6].

Other interactions of LYK5


  1. Emerging roles of pseudokinases. Boudeau, J., Miranda-Saavedra, D., Barton, G.J., Alessi, D.R. Trends Cell Biol. (2006) [Pubmed]
  2. STRAD in Peutz-Jeghers syndrome and sporadic cancers. de Leng, W.W., Keller, J.J., Luiten, S., Musler, A.R., Jansen, M., Baas, A.F., de Rooij, F.W., Gille, J.J., Menko, F.H., Offerhaus, G.J., Weterman, M.A. J. Clin. Pathol. (2005) [Pubmed]
  3. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Baas, A.F., Kuipers, J., van der Wel, N.N., Batlle, E., Koerten, H.K., Peters, P.J., Clevers, H.C. Cell (2004) [Pubmed]
  4. Analysis of the LKB1-STRAD-MO25 complex. Boudeau, J., Scott, J.W., Resta, N., Deak, M., Kieloch, A., Komander, D., Hardie, D.G., Prescott, A.R., van Aalten, D.M., Alessi, D.R. J. Cell. Sci. (2004) [Pubmed]
  5. Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. Milburn, C.C., Boudeau, J., Deak, M., Alessi, D.R., van Aalten, D.M. Nat. Struct. Mol. Biol. (2004) [Pubmed]
  6. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. Baas, A.F., Boudeau, J., Sapkota, G.P., Smit, L., Medema, R., Morrice, N.A., Alessi, D.R., Clevers, H.C. EMBO J. (2003) [Pubmed]
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