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Gene Review

PFDN1  -  prefoldin subunit 1

Homo sapiens

Synonyms: PDF, PFD1, Prefoldin subunit 1
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Disease relevance of PFDN1

  • No significant differences in peritonitis-free interval or peritonitis rate could be attributed to the prescribed PDF [1].

High impact information on PFDN1

  • Deletion of the gene encoding a prefoldin subunit in S. cerevisiae results in a phenotype similar to those found when c-cpn is mutated, namely impaired functions of the actin and tubulin-based cytoskeleton [2].
  • Cromoglycate treatment also completely prevented PDF-induced omental adhesions to the catheter tip (P = 0.0002) [3].
  • Data strongly support the hypothesis that mast cells mediate PDF-induced omental tissue remodeling and, subsequently, peritoneal cell influx and adhesion formation, providing therapeutic possibilities of modulating omental function [3].


  1. Changing prescribing practice in CAPD patients in Korea: increased utilization of low GDP solutions improves patient outcome. Lee, H.Y., Choi, H.Y., Park, H.C., Seo, B.J., Do, J.Y., Yun, S.R., Song, H.Y., Kim, Y.H., Kim, Y.L., Kim, D.J., Kim, Y.S., Kim, M.J., Shin, S.K. Nephrol. Dial. Transplant. (2006) [Pubmed]
  2. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Vainberg, I.E., Lewis, S.A., Rommelaere, H., Ampe, C., Vandekerckhove, J., Klein, H.L., Cowan, N.J. Cell (1998) [Pubmed]
  3. Novel role for mast cells in omental tissue remodeling and cell recruitment in experimental peritoneal dialysis. Zareie, M., Fabbrini, P., Hekking, L.H., Keuning, E.D., Ter Wee, P.M., Beelen, R.H., van den Born, J. J. Am. Soc. Nephrol. (2006) [Pubmed]
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