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Chemical Compound Review

cromolyn     5-[3-(2-carboxy-4-oxo- chromen-5-yl)oxy-2...

Synonyms: Frenasma, Rynacrom, Lomudal, Nalcrom, Aarane, ...
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Disease relevance of Disodium cromoglycate


Psychiatry related information on Disodium cromoglycate


High impact information on Disodium cromoglycate

  • Thus although patients tolerating cromolyn therapy may demonstrate lymphocyte transformation in vitro, only those with clinically apparent adverse reactions produce lymphocyte MIF or possess serum-binding activity for the drug [1].
  • Lymphocytes from four of nine cromolyn-tolerant asthmatics demonstrated increased 3H-thymidine incorporation but none showed MIF production, whereas lymphocytes from normal subjects failed to react to cromolyn in either assay [1].
  • Cromoglycate, which inhibits IgE-mediated degranulation of mast cells and a basophilic rat tumour cell line (RBL-2H3) (ref.3), is a drug widely used in the treatment of allergic asthma [8].
  • Basophil variants with impaired cromoglycate binding do not respond to an immunological degranulation stimulus [8].
  • These findings together with the chelation by cromoglycate of alkaline-earth ions in low polarity medium, suggest that the binding site of the drug may either be part, or closely related to the calcium gate [8].

Chemical compound and disease context of Disodium cromoglycate


Biological context of Disodium cromoglycate


Anatomical context of Disodium cromoglycate

  • Lymphocytes from all patients produced migration inhibition factor (MIF), and those from four patients incorporated increased amounts of 3H-thymidine in response to cromolyn in vitro [1].
  • To further investigate this, we have selected variants of the RBL-2H3 cell line that are defective in cromoglycate binding but bind IgE normally [8].
  • Conductances of both types of planar membranes, irrespective of the mode of activation used, were inhibited by cromolyn [18].
  • In contrast, preincubation of neutrophils with 100 microM cromolyn before addition of PMA decreased the capacity of the membranes to generate O2- by 57.3% [19].
  • Cromolyn treatment over days 9 to 12 reduced joint swelling but increased leukocyte emigration into the mesentery [20].

Associations of Disodium cromoglycate with other chemical compounds


Gene context of Disodium cromoglycate


Analytical, diagnostic and therapeutic context of Disodium cromoglycate


  1. Immunologic components of hypersensitivity reactions to cromolyn sodium. Sheffer, A.L., Rocklin, R.E., Goetzl, E.J. N. Engl. J. Med. (1975) [Pubmed]
  2. A binding site on mast cells and basophils for the anti-allergic drug cromolyn. Mazurek, N., Berger, G., Pecht, I. Nature (1980) [Pubmed]
  3. Esophagitis related to cromolyn. Israel, R.H., Wood, J. JAMA (1979) [Pubmed]
  4. Use of cromolyn in combined gastrointestinal allergy. Kocoshis, S., Gryboski, J.D. JAMA (1979) [Pubmed]
  5. Therapy with cromolyn sodium. Bernstein, I.L., Johnson, C.L. Ann. Intern. Med. (1978) [Pubmed]
  6. Evaluation of ketotifen (HC20-511) in bronchial asthma. Paterson, J.W., Yellin, R.H., Tarala, R.A. Eur. J. Clin. Pharmacol. (1983) [Pubmed]
  7. Twice daily 4% Sodium Cromoglycate vs. 2% Sodium Cromoglycate used four times daily in seasonal (grass pollen) allergic conjunctivitis. Collum, L.M., Fitzsimon, S., Hillery, M., Collum, A., Power, W.J., Pelikan, Z., Jenson, J.B. Documenta ophthalmologica. Advances in ophthalmology. (1992) [Pubmed]
  8. Basophil variants with impaired cromoglycate binding do not respond to an immunological degranulation stimulus. Mazurek, N., Bashkin, P., Petrank, A., Pecht, I. Nature (1983) [Pubmed]
  9. Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents. Cattaruzza, F., Cenac, N., Barocelli, E., Impicciatore, M., Hyun, E., Vergnolle, N., Sternini, C. Am. J. Pathol. (2006) [Pubmed]
  10. Pharmacotherapy for asthma and chronic obstructive pulmonary disease. Current thinking, practices, and controversies. Skorodin, M.S. Arch. Intern. Med. (1993) [Pubmed]
  11. Comparative efficacy of salbutamol, ipratropium, and cromoglycate in the prevention of bronchospasm induced by exercise and hyperosmolar challenges. Boulet, L.P., Turcotte, H., Tennina, S. J. Allergy Clin. Immunol. (1989) [Pubmed]
  12. Effect of inhaled iodoxamide tromethamine in prevention of antigen-induced bronchospasm. Ungerer, R.G., Tashkin, D.P., Siegel, S.C., Deutsch, R.I. J. Allergy Clin. Immunol. (1981) [Pubmed]
  13. Contributions of Histamine, Prostanoids, and Neurokinins to Edema Elicited by Edema Toxin from Bacillus anthracis. Tessier, J., Green, C., Padgett, D., Zhao, W., Schwartz, L., Hughes, M., Hewlett, E. Infect. Immun. (2007) [Pubmed]
  14. Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein. Theoharides, T.C., Sieghart, W., Greengard, P., Douglas, W.W. Science (1980) [Pubmed]
  15. Cromolyn therapy in patients with bronchial asthma. Effect on inhalation challenge with allergen, histamine, and methacholine. Ryo, U.Y., Kang, B., Townley, R.G. JAMA (1976) [Pubmed]
  16. Nasal exhalation of cromolyn: a double effect. Berger, G.W. JAMA (1991) [Pubmed]
  17. Immunologically activated chloride channels involved in degranulation of rat mucosal mast cells. Romanin, C., Reinsprecht, M., Pecht, I., Schindler, H. EMBO J. (1991) [Pubmed]
  18. The cromolyn binding protein constitutes the Ca2+ channel of basophils opening upon immunological stimulus. Mazurek, N., Schindler, H., Schürholz, T., Pecht, I. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  19. Cromolyn inhibits assembly of the NADPH oxidase and superoxide anion generation by human neutrophils. Kilpatrick, L.E., Jakabovics, E., McCawley, L.J., Kane, L.H., Korchak, H.M. J. Immunol. (1995) [Pubmed]
  20. A role for mast cells in the development of adjuvant-induced vasculitis and arthritis. Johnston, B., Burns, A.R., Kubes, P. Am. J. Pathol. (1998) [Pubmed]
  21. Has the change to beta-agonists combined with oral theophylline increased cases of fatal asthma? Wilson, J.D., Sutherland, D.C., Thomas, A.C. Lancet (1981) [Pubmed]
  22. Liver disease and vasculitis in a patient taking cromolyn. Rosenberg, J.L., Edlow, D., Sneider, R. Arch. Intern. Med. (1978) [Pubmed]
  23. Beclomethasone given after the early asthmatic response inhibits the late response and the increased methacholine responsiveness and cromolyn does not. Cockcroft, D.W., McParland, C.P., O'Byrne, P.M., Manning, P., Friend, J.L., Rutherford, B.C., Swystun, V.A. J. Allergy Clin. Immunol. (1993) [Pubmed]
  24. Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice. Huang, M., Pang, X., Karalis, K., Theoharides, T.C. Cardiovasc. Res. (2003) [Pubmed]
  25. Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. Shishibori, T., Oyama, Y., Matsushita, O., Yamashita, K., Furuichi, H., Okabe, A., Maeta, H., Hata, Y., Kobayashi, R. Biochem. J. (1999) [Pubmed]
  26. Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Theoharides, T.C., Singh, L.K., Boucher, W., Pang, X., Letourneau, R., Webster, E., Chrousos, G. Endocrinology (1998) [Pubmed]
  27. Cloning and cellular localization of the rat mast cell 78-kDa protein phosphorylated in response to the mast cell "stabilizer" cromolyn. Theoharides, T.C., Wang, L., Pang, X., Letourneau, R., Culm, K.E., Basu, S., Wang, Y., Correia, I. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  28. Inhaled steroids and the risk of hospitalization for asthma. Donahue, J.G., Weiss, S.T., Livingston, J.M., Goetsch, M.A., Greineder, D.K., Platt, R. JAMA (1997) [Pubmed]
  29. Cromolyn for chemotherapy conjunctivitis. Cohen, J.M. J. Clin. Oncol. (1985) [Pubmed]
  30. Polyacrolein microspheres as a new tool in cell biology. Margel, S., Beitler, U., Ofarim, M. J. Cell. Sci. (1982) [Pubmed]
  31. New directions and dimensions in the treatment of allergic rhinitis. Busse, W. J. Allergy Clin. Immunol. (1988) [Pubmed]
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