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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cbx7  -  chromobox 7

Mus musculus

Synonyms: 1600014J01Rik, AI851678, Chromobox protein homolog 7, D15Ertd417e
 
 
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Disease relevance of Cbx7

  • By targeting Cbx7 expression to the lymphoid compartment in mice, we showed that Cbx7 can initiate T cell lymphomagenesis and cooperate with c-Myc to produce highly aggressive B cell lymphomas [1].
 

High impact information on Cbx7

  • Finally, we find that, in vitro, the chromodomain of Cbx7 can bind RNA and that, in vivo, the interaction of Cbx7 with chromatin, and the inactive X chromosome in particular, depends partly on its association with RNA [2].

References

  1. Role of the chromobox protein CBX7 in lymphomagenesis. Scott, C.L., Gil, J., Hernando, E., Teruya-Feldstein, J., Narita, M., Martínez, D., Visakorpi, T., Mu, D., Cordon-Cardo, C., Peters, G., Beach, D., Lowe, S.W. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  2. Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Bernstein, E., Duncan, E.M., Masui, O., Gil, J., Heard, E., Allis, C.D. Mol. Cell. Biol. (2006) [Pubmed]
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