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Gene Review

CBX7  -  chromobox homolog 7

Homo sapiens

Synonyms: Chromobox protein homolog 7
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Disease relevance of CBX7


High impact information on CBX7

  • CBX7 does not inter-function or colocalize with Bmi1, and both can exert their actions independently of each other as shown by reverse genetics [3].
  • In a genetic screen for cDNAs bypassing replicative senescence of normal human prostate epithelial cells (HPrEC), we identified CBX7, a gene that encodes a Polycomb protein, as shown by sequence homology, its interaction with Ring1 and its localization to nuclear Polycomb bodies [3].
  • These data identify CBX7 as a chromobox protein causally linked to cancer development and may help explain the low frequency of INK4a/ARF mutations observed in human follicular lymphoma [1].
  • CBX7 knockdown caused an impairment of cell growth that was dependent on the status of the p14Arf/p53 and p16Ink4a/Rb pathways in both normal and cancer prostate cells [2].
  • In an attempt to identify a putative role of CBX7 in tumorigenesis, we analysed CBX7 expression in a panel of cancer cell lines and primary tissues [2].

Biological context of CBX7

  • Ablation of CBX7 expression using short hairpin RNAs (shRNA) resulted in upregulation of p16Ink4a and p14Arf in both LNCaP and PC-3 prostate cell lines [2].

Associations of CBX7 with chemical compounds

  • CBX7 overexpression in LNCaP cells resulted in a slight growth advantage in both androgen-dependent and -independent conditions [2].


  1. Role of the chromobox protein CBX7 in lymphomagenesis. Scott, C.L., Gil, J., Hernando, E., Teruya-Feldstein, J., Narita, M., Martínez, D., Visakorpi, T., Mu, D., Cordon-Cardo, C., Peters, G., Beach, D., Lowe, S.W. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  2. CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus. Bernard, D., Martinez-Leal, J.F., Rizzo, S., Martinez, D., Hudson, D., Visakorpi, T., Peters, G., Carnero, A., Beach, D., Gil, J. Oncogene (2005) [Pubmed]
  3. Polycomb CBX7 has a unifying role in cellular lifespan. Gil, J., Bernard, D., Martínez, D., Beach, D. Nat. Cell Biol. (2004) [Pubmed]
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