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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FXYD7  -  FXYD domain containing ion transport...

Homo sapiens

Synonyms: FXYD domain-containing ion transport regulator 7
 
 
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High impact information on FXYD7

  • In this study, we have investigated the tissue distribution and the structural and functional properties of FXYD7, another family member which has not yet been characterized [1].
  • Expressed exclusively in the brain, FXYD7 is a type I membrane protein bearing N-terminal, post-translationally added modifications on threonine residues, most probably O-glycosylations that are important for protein stabilization [1].
  • Expressed in Xenopus oocytes, FXYD7 can interact with Na,K-ATPase alpha 1-beta 1, alpha 2-beta 1 and alpha 3-beta 1 but not with alpha-beta 2 isozymes, whereas, in brain, it is only associated with alpha 1-beta isozymes [1].
  • FXYD7, the first brain- and isoform-specific regulator of Na,K-ATPase: biosynthesis and function of its posttranslational modifications [2].
  • The mammalian FXYD proteins FXYD1 through FXYD7 exhibit tissue-specific distribution [3].

References

  1. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. Béguin, P., Crambert, G., Monnet-Tschudi, F., Uldry, M., Horisberger, J.D., Garty, H., Geering, K. EMBO J. (2002) [Pubmed]
  2. FXYD7, the first brain- and isoform-specific regulator of Na,K-ATPase: biosynthesis and function of its posttranslational modifications. Crambert, G., Béguin, P., Uldry, M., Monnet-Tschudi, F., Horisberger, J.D., Garty, H., Geering, K. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  3. FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase. Crambert, G., Geering, K. Sci. STKE (2003) [Pubmed]
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