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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gp9  -  glycoprotein 9 (platelet)

Mus musculus

Synonyms: Cd42, GP-IX, GPIX, Glycoprotein 9, Platelet glycoprotein IX
 
 
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Disease relevance of Gp9

 

High impact information on Gp9

  • This pattern of selection is remarkably similar to that observed for the maternal effect selfish genes, Medea in flour beetles and scat in the mouse, and the Gp-9 gene in the fire ant [2].
  • The deduced amino-acid sequence (177aa) was 71% identical to the human GPIX protein [3].
  • Mouse GPIX contained a leucine-rich glycoprotein sequence composed of 24 amino acids, as did human GPIX [3].

References

  1. Ultrastructural analysis of megakaryocytes in GPV knockout mice. Poujol, C., Ramakrishnan, V., DeGuzman, F., Nurden, A.T., Phillips, D.R., Nurden, P. Thromb. Haemost. (2000) [Pubmed]
  2. Opposing levels of selection can cause neutrality: mating patterns and maternal-fetal interactions. Wade, M.J. Evolution (2000) [Pubmed]
  3. Characterization of cDNA encoding full-length mouse platelet glycoprotein IX. Kitaguchi, T., Murata, M., Ambo, H., Ikeda, Y. Blood Coagul. Fibrinolysis (1998) [Pubmed]
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