Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CHPF2 - chondroitin polymerizing factor 2

Homo sapiens

Synonyms: CHSY3, CSGLCA-T, CSGLCAT, CSGlcA-T, CSGlcAT, ...

Yada, T. et al., Izumikawa, T. et al., Gotoh, M. et al.

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High impact information on CHPF2

Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities [1].
We found a novel human gene (GenBank accession number AB086063) that possesses a sequence homologous with the human chondroitin sulfate glucuronyltransferase gene which we recently cloned and characterized [1].
Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine [2].

Physical interactions of CHPF2

The analysis using the CSGlcA-T mutant that lacks any glycosyltransferase activity but interacts with other ChSy family members showed that the glycosyltransferase activity of CSGlcA-T plays an important role in chondroitin polymerization [3].

References

Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities. Yada, T., Gotoh, M., Sato, T., Shionyu, M., Go, M., Kaseyama, H., Iwasaki, H., Kikuchi, N., Kwon, Y.D., Togayachi, A., Kudo, T., Watanabe, H., Narimatsu, H., Kimata, K. J. Biol. Chem. (2003) [Pubmed]
Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine. Gotoh, M., Yada, T., Sato, T., Akashima, T., Iwasaki, H., Mochizuki, H., Inaba, N., Togayachi, A., Kudo, T., Watanabe, H., Kimata, K., Narimatsu, H. J. Biol. Chem. (2002) [Pubmed]
Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. Izumikawa, T., Koike, T., Shiozawa, S., Sugahara, K., Tamura, J., Kitagawa, H. J. Biol. Chem. (2008) [Pubmed]

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