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Gene Review

EXOSC4  -  exosome component 4

Homo sapiens

Synonyms: Exosome complex component RRP41, Exosome component 4, FLJ20591, RRP41, RRP41A, ...
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High impact information on EXOSC4

  • Recombinant Rrp4p, Rrp44p, and Rrp41p are 3'-->5' exoribonucleases in vitro that have distributive, processive, and phosphorolytic activities, respectively [1].
  • Production of these mRNAs was suppressed by depletion of Rrp41p, indicating that they are the products of exosome processing followed by uncoupled polyadenylation [2].
  • This interaction is most likely mediated by protein-protein interactions with two other exosome subunits, hRrp46p and hRrp41p, one of which was confirmed in a mammalian two-hybrid system [3].
  • We conclude that hRrp40p, hRrp41p, and hRrp46p represent novel components of the human exosome complex [4].
  • While nine (33%) were heterozygous for the P12A variant, c.34C/G (cytosine to guanine change at nucleotide 34), 12 (15%) controls were heterozygous for P12A (p<0.05) [5].

Other interactions of EXOSC4

  • In addition, the results of co-immunoprecipitation assays indicate that at least two copies of hRrp4p and hRrp41p are associated with a single exosome, suggesting that at least two of these ring structures are present in this complex [6].

Analytical, diagnostic and therapeutic context of EXOSC4


  1. The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Mitchell, P., Petfalski, E., Shevchenko, A., Mann, M., Tollervey, D. Cell (1997) [Pubmed]
  2. Processing of 3'-extended read-through transcripts by the exosome can generate functional mRNAs. Torchet, C., Bousquet-Antonelli, C., Milligan, L., Thompson, E., Kufel, J., Tollervey, D. Mol. Cell (2002) [Pubmed]
  3. The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. Raijmakers, R., Egberts, W.V., van Venrooij, W.J., Pruijn, G.J. J. Biol. Chem. (2003) [Pubmed]
  4. Three novel components of the human exosome. Brouwer, R., Allmang, C., Raijmakers, R., van Aarssen, Y., Egberts, W.V., Petfalski, E., van Venrooij, W.J., Tollervey, D., Pruijn, G.J. J. Biol. Chem. (2001) [Pubmed]
  5. Over-representation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population. Zhou, X.P., Smith, W.M., Gimm, O., Mueller, E., Gao, X., Sarraf, P., Prior, T.W., Plass, C., von Deimling, A., Black, P.M., Yates, A.J., Eng, C. J. Med. Genet. (2000) [Pubmed]
  6. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. Raijmakers, R., Egberts, W.V., van Venrooij, W.J., Pruijn, G.J. J. Mol. Biol. (2002) [Pubmed]
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