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EXOSC5  -  exosome component 5

Homo sapiens

Synonyms: CML28, Chronic myelogenous leukemia tumor antigen 28, Exosome complex component RRP46, Exosome component 5, MGC12901, ...
 
 
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Disease relevance of EXOSC5

 

High impact information on EXOSC5

 

Biological context of EXOSC5

  • These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs [6].
  • One of the tested peptides, CML28((173-181)), induced peptide-specific CTLs in vitro as well as in vivo, which could specifically secrete IFN-gamma and lyse major histocompatibility complex (MHC)-matched tumor cell lines endogenously expressing CML28 antigen and CML28((173-181) )pulsed Jurkat-A2/Kb cells, respectively [2].
  • The results showed that recombinant plasmid pcDNA3.1HisA-CML28 contained the correct full CML28 cDNA identified by restriction analysis and sequencing, and can express the fusion protein His-CML28 in DCs [7].
  • The primers p24E and p12B were employed in the PCR assay to amplify a 296 bp fragment of the Bartonella 16S rRNA gene [8].
 

Anatomical context of EXOSC5

 

Other interactions of EXOSC5

 

Analytical, diagnostic and therapeutic context of EXOSC5

  • Moreover, given its expression and immunogenicity in a wide variety of malignancies, CML28 merits additional evaluation as a target for antigen-specific immunotherapy [4].
  • Western blotting with CML28 monoclonal antibody against whole-cell lysates derived from blood and marrow of normal donors and patients with leukemia revealed high expression of this antigen in tumor but not in normal samples [4].
  • The full length of CML28 cDNA was amplified from K562 by RT-PCR and subcloned into pGEM-T vector [7].

References

  1. Graft-versus-leukemia target antigens in chronic myelogenous leukemia are expressed on myeloid progenitor cells. Wu, C.J., Biernacki, M., Kutok, J.L., Rogers, S., Chen, L., Yang, X.F., Soiffer, R.J., Ritz, J. Clin. Cancer Res. (2005) [Pubmed]
  2. Identification of a new HLA-A*0201-restricted cytotoxic T lymphocyte epitope from CML28. Han, J.F., Zhao, T.T., Liu, H.L., Lin, Z.H., Wang, H.M., Ruan, Z.H., Zou, L.Y., Wu, Y.Z. Cancer Immunol. Immunother. (2006) [Pubmed]
  3. Bartonella henselae is a causative agent of cat scratch disease in Australia. Flexman, J.P., Lavis, N.J., Kay, I.D., Watson, M., Metcalf, C., Pearman, J.W. J. Infect. (1995) [Pubmed]
  4. CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells. Yang, X.F., Wu, C.J., Chen, L., Alyea, E.P., Canning, C., Kantoff, P., Soiffer, R.J., Dranoff, G., Ritz, J. Cancer Res. (2002) [Pubmed]
  5. The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. Raijmakers, R., Egberts, W.V., van Venrooij, W.J., Pruijn, G.J. J. Biol. Chem. (2003) [Pubmed]
  6. Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector. Zhou, H., Zhang, D., Wang, Y., Dai, M., Zhang, L., Liu, W., Liu, D., Tan, H., Huang, Z. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  7. Construction and expression of dendritic cell nucleic acid vaccine containing CML28 gene in human dendritic cells. Zhang, D.H., Zhou, H.S., Wang, Y.Y., Liu, W.L., Huang, Z.Q., Tan, H. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2005) [Pubmed]
  8. Cat scratch disease. Survey on the presence of Bartonella henselae among cats of Tuscany. Ebani, V.V., Cerri, D., Andreani, E. New Microbiol. (2002) [Pubmed]
  9. Three novel components of the human exosome. Brouwer, R., Allmang, C., Raijmakers, R., van Aarssen, Y., Egberts, W.V., Petfalski, E., van Venrooij, W.J., Tollervey, D., Pruijn, G.J. J. Biol. Chem. (2001) [Pubmed]
  10. Protein-protein interactions of hCsl4p with other human exosome subunits. Raijmakers, R., Noordman, Y.E., van Venrooij, W.J., Pruijn, G.J. J. Mol. Biol. (2002) [Pubmed]
 
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