Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

RC3H2 - ring finger and CCCH-type domains 2

Homo sapiens

Synonyms: FLJ20301, FLJ20713, MNAB, Membrane-associated nucleic acid-binding protein, RING finger and CCCH-type zinc finger domain-containing protein 2, ...

Siess, D.C. et al.

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High impact information on RC3H2

The MNAB gene is on human chromosome 9 with wide expression in normal tissues and tumor cells [1].
MNAB bound DNA (K(D) approximately 4 nm) and mutagenesis of a single conserved amino acid in the zinc finger reduced DNA binding by 50% [1].
The MNAB protein is membrane-associated and primarily localized to the perinuclear space, probably to the endoplasmic reticulum or trans-Golgi network [1].

References

A human gene coding for a membrane-associated nucleic acid-binding protein. Siess, D.C., Vedder, C.T., Merkens, L.S., Tanaka, T., Freed, A.C., McCoy, S.L., Heinrich, M.C., Deffebach, M.E., Bennett, R.M., Hefeneider, S.H. J. Biol. Chem. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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