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Gene Review

GNL3L  -  guanine nucleotide binding protein-like 3...

Homo sapiens

Synonyms: FLJ10613, Guanine nucleotide-binding protein-like 3-like protein
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Disease relevance of GNL3L


High impact information on GNL3L

  • Heterologous expression of GNL3L in a Deltagrn1 mutant restored processing of 35S pre-rRNA, nuclear export of Rpl25a and cell growth to wild-type levels [2].
  • Grn1p from fission yeast and GNL3L from human cells, two putative GTPases from the novel HSR1_MMR1 GTP-binding protein subfamily with circularly permuted G-motifs play a critical role in maintaining normal cell growth [2].
  • Genetic complementation in yeast and siRNA knockdown in HeLa cells confirmed the homologous proteins Grn1p and GNL3L are required for growth [2].
  • We demonstrate here that GNL3L is transported into the nucleolus by a novel lysine-rich nucleolar localization signal (NoLS) residing within 1-50 amino acid residues [1].
  • We describe here a new evolutionarily conserved putative human GTPase, guanine nucleotide binding protein-like 3-like (GNL3L) [1].


  1. A Novel Lysine-rich Domain and GTP Binding Motifs Regulate the Nucleolar Retention of Human Guanine Nucleotide Binding Protein, GNL3L. Rao, M.R., Kumari, G., Balasundaram, D., Sankaranarayanan, R., Mahalingam, S. J. Mol. Biol. (2006) [Pubmed]
  2. The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA. Du, X., Rao, M.R., Chen, X.Q., Wu, W., Mahalingam, S., Balasundaram, D. Mol. Biol. Cell (2006) [Pubmed]
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