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Gene Review

PARP14  -  poly (ADP-ribose) polymerase family,...

Homo sapiens

Synonyms: ADP-ribosyltransferase diphtheria toxin-like 8, ARTD8, B aggressive lymphoma protein 2, BAL2, KIAA1268, ...
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High impact information on PARP14

  • Of note, the BAL N-terminus and secondary structure resemble those of a recently identified human protein, KIAA1268 [1].
  • In addition, we show that BAL2 and BAL3, but not BAL1, exhibit PARP activity [2].
  • In agreement with these data, BAL1 lacks several critical donor and acceptor residues that are conserved in the BAL2 and -3 PARP active sites [2].

Biological context of PARP14

  • In addition, both BAL and KIAA1268 map to chromosome 3q21, further suggesting that these genes belong to a newly identified family [1].

Analytical, diagnostic and therapeutic context of PARP14

  • Of the 59 patients undergoing BAL 2 or more weeks after transplantation there were 16 specimens from 14 patients (24%) positive for P carinii [3].


  1. BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. Aguiar, R.C., Yakushijin, Y., Kharbanda, S., Salgia, R., Fletcher, J.A., Shipp, M.A. Blood (2000) [Pubmed]
  2. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. Aguiar, R.C., Takeyama, K., He, C., Kreinbrink, K., Shipp, M.A. J. Biol. Chem. (2005) [Pubmed]
  3. The spectrum of Pneumocystis carinii infection after liver transplantation in children. Colombo, J.L., Sammut, P.H., Langnas, A.N., Shaw, B.W. Transplantation (1992) [Pubmed]
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