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Gene Review:

RNF43 - ring finger protein 43

Homo sapiens

Synonyms: DKFZp781H0392, E3 ubiquitin-protein ligase RNF43, FLJ20315, RING finger protein 43, RNF124, ...

Yagyu, R. et al., Hickok, J.T. et al., Uchida, N. et al.

Hickok, Roscoe, Morrow, Bole, Zhao, Hoelzer, Dakhil, Moore, Fitch,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RNF43

These results strongly suggest that RNF43 is a new TAA of colon cancer [1].
A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer [2].

High impact information on RNF43

Interestingly, RNF43 protein was shown to be a secreted protein, and addition of the conditioned media of the RNF43-transfected cells into culture media of NIH3T3 cells revealed a significant enhancement of cell growth [2].
5-Hydroxytryptamine-receptor antagonists versus prochlorperazine for control of delayed nausea caused by doxorubicin: a URCC CCOP randomised controlled trial [3].

Analytical, diagnostic and therapeutic context of RNF43

Multiple-tissue northern blot analysis revealed undetectable expression of RNF43 in normal adult tissues examined and low levels of expression in fetal kidney and lung [2].
Ring finger protein 43 as a new target for cancer immunotherapy [1].

References

Ring finger protein 43 as a new target for cancer immunotherapy. Uchida, N., Tsunoda, T., Wada, S., Furukawa, Y., Nakamura, Y., Tahara, H. Clin. Cancer Res. (2004) [Pubmed]
A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. Yagyu, R., Furukawa, Y., Lin, Y.M., Shimokawa, T., Yamamura, T., Nakamura, Y. Int. J. Oncol. (2004) [Pubmed]
5-Hydroxytryptamine-receptor antagonists versus prochlorperazine for control of delayed nausea caused by doxorubicin: a URCC CCOP randomised controlled trial. Hickok, J.T., Roscoe, J.A., Morrow, G.R., Bole, C.W., Zhao, H., Hoelzer, K.L., Dakhil, S.R., Moore, T., Fitch, T.R. The lancet oncology. (2005) [Pubmed]

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