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Gene Review

ELOVL2  -  ELOVL fatty acid elongase 2

Homo sapiens

Synonyms: 3-keto acyl-CoA synthase ELOVL2, ELOVL FA elongase 2, Elongation of very long chain fatty acids protein 2, SSC2, Ssc2, ...
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High impact information on ELOVL2

  • For back fat thickness, a paternally expressed QTL was found on Sus scrofa chromosome 2 (SSC2), and a Mendelian-expressed QTL was found on SSC7 [1].
  • The peak positions on Sus scrofa chromosomes (SSC) were at 49.4 and 88.0 cM (SSC1), 56.0 cM (SSC13), 86.5 cM (SSC15) and 39.8 cM (SSC17), and, on SSC2, at 16.9 cM, in families derived from F1 males only (p < 0.05, except for SSC13, p < 0.01) [2].
  • This study reports a high-resolution comparative map between human chromosomes and porcine chromosomes 2 (SSC2) and 16 (SSC16), pointing out new homologies and evolutionary breakpoints [3].
  • Among 226 porcine ESTs selected according to their expected localization, 151 were RH mapped and ordered on SSC2 [3].
  • The open reading frame of the human clone (ELOVL2) encodes a 296-amino acid peptide, whereas the mouse clone (Elovl2) encodes a 292-amino acid peptide [4].

Anatomical context of ELOVL2

  • Using the likelihood-ratio test for a categorical trait, 2 QTL for pin nipples were detected on SSC2 and SSC16 (P < 0.01) [5].

Analytical, diagnostic and therapeutic context of ELOVL2

  • Rapid communication: Linkage mapping of the porcine micromolar calcium-activated neutral protease 1 (mu-calpain) gene on SSC2 [6].


  1. Genome-wide scan for body composition in pigs reveals important role of imprinting. de Koning, D.J., Rattink, A.P., Harlizius, B., van Arendonk, J.A., Brascamp, E.W., Groenen, M.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Detection of novel quantitative trait loci for cutaneous melanoma by genome-wide scan in the MeLiM swine model. Zhi-Qiang, D., Silvia, V.N., H??l??ne, G., Florence, V., Fran??oise, C., Takeshi, S., Hiroshi, Y., Jean-Jacques, L., Stephan, B., Joseph, G., Vratislav, H., Denis, M., Roy Pascale, L., Claudine, G. Int. J. Cancer (2007) [Pubmed]
  3. Evolutionary breakpoints through a high-resolution comparative map between porcine chromosomes 2 and 16 and human chromosomes. Lahbib-Mansais, Y., Mompart, F., Milan, D., Leroux, S., Faraut, T., Delcros, C., Yerle, M. Genomics (2006) [Pubmed]
  4. Identification and expression of mammalian long-chain PUFA elongation enzymes. Leonard, A.E., Kelder, B., Bobik, E.G., Chuang, L.T., Lewis, C.J., Kopchick, J.J., Mukerji, P., Huang, Y.S. Lipids (2002) [Pubmed]
  5. Identification of quantitative trait loci affecting corpora lutea and number of teats in a Meishan x Duroc F2 resource population. Sato, S., Atsuji, K., Saito, N., Okitsu, M., Sato, S., Komatsuda, A., Mitsuhashi, T., Nirasawa, K., Hayashi, T., Sugimoto, Y., Kobayashi, E. J. Anim. Sci. (2006) [Pubmed]
  6. Rapid communication: Linkage mapping of the porcine micromolar calcium-activated neutral protease 1 (mu-calpain) gene on SSC2. Smith, T.P., Rohrer, G.A. J. Anim. Sci. (2001) [Pubmed]
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