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GEMIN8  -  gem (nuclear organelle) associated protein 8

Homo sapiens

Synonyms: FAM51A1, FLJ20514, Gem-associated protein 8, Gemin-8, Protein FAM51A1
 
 
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High impact information on GEMIN8

  • Gemin8 is also associated with Sm proteins, and Gemin8-containing SMN complexes are competent to carry out snRNP assembly [1].
  • Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly [1].
  • Here, by mass spectrometry analysis of SMN complexes purified from HeLa cells, we identified a novel protein that is evolutionarily conserved in metazoans, and we named it Gemin8 [1].
  • These results demonstrate that Gemin8 is a novel integral component of the SMN complex and extend the repertoire of cellular proteins involved in the pathway of snRNP biogenesis [1].
  • Here, we have investigated the functional role of Gemin8 using novel monoclonal antibodies against components of the SMN complex and RNA interference experiments [2].
 

Biological context of GEMIN8

 

Analytical, diagnostic and therapeutic context of GEMIN8

  • Co-immunoprecipitation and immunolocalization experiments demonstrated that Gemin8 is associated with the SMN complex and is localized in the cytoplasm and in the nucleus, where it is highly concentrated in Gems [1].

References

  1. Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly. Carissimi, C., Saieva, L., Baccon, J., Chiarella, P., Maiolica, A., Sawyer, A., Rappsilber, J., Pellizzoni, L. J. Biol. Chem. (2006) [Pubmed]
  2. Gemin8 is required for the architecture and function of the survival motor neuron complex. Carissimi, C., Saieva, L., Gabanella, F., Pellizzoni, L. J. Biol. Chem. (2006) [Pubmed]
 
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