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Gene Review:

NOL8 - nucleolar protein 8

Homo sapiens

Synonyms: C9orf34, FLJ20736, NOP132, Nop132, Nucleolar protein 8, ...

Jinawath, N. et al., Sekiguchi, T. et al.

Sekiguchi, Todaka, Wang, Hirose, Nakashima, Nishimoto,

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Disease relevance of NOL8

Comparison of expression profiles between diffuse-type and intestinal-type gastric cancers showed that NOL8 was specifically up-regulated in diffuse-type cancers [1].

High impact information on NOL8

Nop132 also interacts with human Nip7 and is colocalized with RRAG A, RRAG C, and Nip7 [2].
RNA interference knockdown of Nop132 inhibited cell growth of HeLa cells [2].
Northern blot analysis revealed that NOL8 was expressed in skeletal muscle, but not expressed or hardly detectable in 22 other tissues examined [1].
Furthermore, transfection of short-interfering RNA (siRNA) specific to NOL8 into three diffuse-type gastric cancer cells, St-4, MKN45 and TMK-1, effectively reduced expression of this gene and induced apoptosis in these cells [1].

References

Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. Jinawath, N., Furukawa, Y., Nakamura, Y. Cancer Sci. (2004) [Pubmed]
A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. Sekiguchi, T., Todaka, Y., Wang, Y., Hirose, E., Nakashima, N., Nishimoto, T. J. Biol. Chem. (2004) [Pubmed]

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