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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ANO1  -  anoctamin 1, calcium activated chloride...

Homo sapiens

Synonyms: Anoctamin-1, DOG1, Discovered on gastrointestinal stromal tumors protein 1, FLJ10261, ORAOV2, ...
 
 
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Disease relevance of TMEM16A

 

High impact information on TMEM16A [2]

  • Three of the novel proteins (TMEM16A, PHLDB2 and ARHGAP21) were analysed further to show that they have the potential to be developed as therapeutic targets [4].
  • In the process, we determined the genomic structure and normal tissue expression patterns of two recently identified genes, TAOS2/TMEM16A and MRGF, which reside in the amplicon core [5].
  • Here, we characterized the FLJ10261 gene by using bioinformatics [1].
  • Two FLJ10261 isoforms with or without exon 15 were transcribed due to alternative splicing [1].
  • This is the first report on comprehensive characterization of the FLJ10261 gene located within the CCND1-ORAOV1-FGF19-FGF4-FGF3-FLJ10261-FADD-PPFIA1-EMS1 locus on human chromosome 11q13 [1].

 

 

 

 

References

  1. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
  2. Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers. Kashyap, M.K., Marimuthu, A., Kishore, C.J., Peri, S., Keerthikumar, S., Prasad, T.S., Mahmood, R., Rao, S., Ranganathan, P., Sanjeeviah, R.C., Vijayakumar, M., Kumar, K.V., Montgomery, E.A., Kumar, R.V., Pandey, A. Cancer. Biol. Ther. (2009) [Pubmed]
  3. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. West, R.B., Corless, C.L., Chen, X., Rubin, B.P., Subramanian, S., Montgomery, K., Zhu, S., Ball, C.A., Nielsen, T.O., Patel, R., Goldblum, J.R., Brown, P.O., Heinrich, M.C., van de Rijn, M. Am. J. Pathol. (2004) [Pubmed]
  4. Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display. Carles, A., Millon, R., Cromer, A., Ganguli, G., Lemaire, F., Young, J., Wasylyk, C., Muller, D., Schultz, I., Rabouel, Y., Dembélé, D., Zhao, C., Marchal, P., Ducray, C., Bracco, L., Abecassis, J., Poch, O., Wasylyk, B. Oncogene (2006) [Pubmed]
  5. Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma. Huang, X., Godfrey, T.E., Gooding, W.E., McCarty, K.S., Gollin, S.M. Genes Chromosomes Cancer (2006) [Pubmed]
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