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Gene Review:

ARHGAP21 - Rho GTPase activating protein 21

Homo sapiens

Synonyms: ARHGAP10, KIAA1424, Rho GTPase-activating protein 10, Rho GTPase-activating protein 21, Rho-type GTPase-activating protein 21

Bassères, D.S. et al., Katoh, M. et al.

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Disease relevance of ARHGAP21

ARHGAP10 mRNA was expressed in chondrosarcoma, breast cancer, kidney tumors, and brain tumors [1].

High impact information on ARHGAP21

ARHGAP10 isoform A, consisting of exons 1-23, encoded full-length protein (786 aa) [1].
Here, we characterized human ARHGAP10 gene by using bioinformatics [1].
ARHGAP10 gene was found encoding two isoforms due to alternative splicing [1].
ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein [2].
The fact that this gene is highly expressed in muscle and brain, which are highly differentiated tissues, further supports the hypothesis that ARHGAP10 is important for cell differentiation [2].

Biological context of ARHGAP21

Real-time quantitative PCR analysis confirmed an increase in ARHGAP10 expression during differentiation of HL-60 cells with all-trans-retinoic acid and hematopoietic stem cells with erythropoietin, suggesting that this gene could play a role in normal hematopoiesis [2].

References

Characterization of human ARHGAP10 gene in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. Bassères, D.S., Tizzei, E.V., Duarte, A.A., Costa, F.F., Saad, S.T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]

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ARHGAP21	Bos taurus
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arhgap21b	Danio rerio
ARHGAP21	Gallus gallus
ARHGAP21	Macaca mulatta
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ARHGAP21	Pan troglodytes
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arhgap21	Xenopus (Silurana) tropicalis

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