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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PPP2R2C  -  protein phosphatase 2, regulatory subunit...

Homo sapiens

Synonyms: B55-GAMMA, IMYPNO, IMYPNO1, MGC33570, PP2A subunit B isoform B55-gamma, ...
 
 
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Disease relevance of PPP2R2C

  • Two T-cell lines were established from peripheral blood mononuclear cells of two Moroccan patients with tropical spastic paraparesis and then named PR52 and PR144 [1].
  • Plantar ulcers are found in feet with foot sole Shore values of 30, a sensation level of 45 mN and PR of 35; for Shore values of 40, sensation levels of 100 mN, with PR 52; and for Shore values above 40, sensation level > 100 mN with PR 58 [2].
 

High impact information on PPP2R2C

  • The putative protein shares 81 and 85% identity with B1alpha (PPP2R2A) and B1beta (PPP2R2B), respectively, and was named PPP2R2C for its high level of homology to the other two isoforms [3].
  • Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16 [3].
 

Analytical, diagnostic and therapeutic context of PPP2R2C

  • In addition, the PPP2R2C gene was localized to human chromosome 4p16 between markers D4S2925 and D4S3007 with 5.45 cR (LOD > 14) and 2.63 cR (LOD > 15) RH distance, respectively, by radiation hybrid panel mapping [3].

References

  1. Establishment of T-lymphoid cell lines from Morroccan patients with tropical spastic paraparesis. Farouqi, B., Yahyaoui, M., Alaoui, F.M., Noraz, N., Sekkat, S., Chkili, T., Desgranges, C., Benslimane, A. AIDS Res. Hum. Retroviruses (1992) [Pubmed]
  2. Effect of foot sole hardness, thickness and footwear on foot pressure distribution parameters in diabetic neuropathy. Charanya, G., Patil, K.M., Narayanamurthy, V.B., Parivalavan, R., Visvanathan, K. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine. (2004) [Pubmed]
  3. Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16. Hu, P., Yu, L., Zhang, M., Zheng, L., Zhao, Y., Fu, Q., Zhao, S. Genomics (2000) [Pubmed]
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