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MeSH Review

Foot Ulcer

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Disease relevance of Foot Ulcer


High impact information on Foot Ulcer

  • Endocrinologists appeared to achieve better foot-ulcer and infection outcomes for patients with NIDDM, particularly when compared with family practitioners [6].
  • The aim of the present study was to investigate the effect of dalteparin on ulcer outcome in patients with diabetes, peripheral arterial occlusive disease, and chronic foot ulcers [7].
  • CONCLUSIONS: DH Pressure Relief Walkers were as effective as total contact casts to reduce foot pressures at ulcer sites and may be an effective practical addition in the treatment of foot ulcers [8].
  • OBJECTIVE--To assess the efficacy and safety of topical human recombinant basic fibroblast growth factor (bFGF) on the healing of diabetic neurotrophic foot ulcers [9].
  • OBJECTIVE: To determine the efficacy and safety of short-contact administration of topical tretinoin on foot ulcers in patients with diabetes [10].

Chemical compound and disease context of Foot Ulcer


Biological context of Foot Ulcer

  • In conclusion, topical ketanserin significantly accelerated wound healing in diabetic neurotrophic foot ulcers when applied as part of a comprehensive healing program [15].
  • Entry criteria included: non-reconstructible PAOD as proven by intra-arterial angiography or patient condition, ankle systolic pressure < 50 mmHg, severe rest pain despite analgetic medication, and presence of nonhealing foot ulcers or dry gangrene [16].

Gene context of Foot Ulcer

  • 3-OH-acyl-CoA-dehydrogenase, citrate synthase and cytochrome-c-oxidase activities were still comparatively high in patients with gangrenous foot ulcers, indicating some maintenance of the muscle viability even in situations with very low blood flow [17].
  • Even though foot ulcers are more likely to develop in patients with diabetic nephropathy, they are no less likely to heal than are those in diabetic patients with normal renal function [18].
  • In addition, subjects with recurrent foot ulcers had significantly higher plasma nitric oxide compared to subjects with non-recurrent foot ulcers (46.9 +/- 6.3 microm/L versus 30.2 +/- 2.4 microm/L respectively, P < 0.01) [12].
  • Her clinical findings included osteosarcoma, nuclear and subcapsular cataracts, insulin-resistant diabetes mellitus, osteoporosis, epilepsy, foot ulcers, erythroid macrocytosis, and unusual facial appearance [19].
  • In patients with an infected foot ulcer, encouraging results were obtained with the granulocyte-colony stimulating factor, Filgrastim [20].

Analytical, diagnostic and therapeutic context of Foot Ulcer


  1. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Verhoeven, K., De Jonghe, P., Coen, K., Verpoorten, N., Auer-Grumbach, M., Kwon, J.M., FitzPatrick, D., Schmedding, E., De Vriendt, E., Jacobs, A., Van Gerwen, V., Wagner, K., Hartung, H.P., Timmerman, V. Am. J. Hum. Genet. (2003) [Pubmed]
  2. Use of Sulesomab, a radiolabeled antibody fragment, to detect osteomyelitis in diabetic patients with foot ulcers by leukoscintigraphy. Harwood, S.J., Valdivia, S., Hung, G.L., Quenzer, R.W. Clin. Infect. Dis. (1999) [Pubmed]
  3. Suspected toxicity from an iodoform preparation in a diabetic patient with multiple foot ulcers. Matsumura, Y., Tsuji, A., Izawa, J., Kumakura, A., Hiramatsu, M., Kogo, K., Takahashi, K., Inoue, Y., Harada, H., Tonozuka, N. Diabet. Med. (2005) [Pubmed]
  4. How much of a priority is treating erectile dysfunction? A study of patients' perceptions. Rance, J., Phillips, C., Davies, S., O'Malley, B., Zaman, Q., Price, D. Diabet. Med. (2003) [Pubmed]
  5. Methicillin-resistant Staphylococcus aureus: an increasing problem in a diabetic foot clinic. Tentolouris, N., Jude, E.B., Smirnof, I., Knowles, E.A., Boulton, A.J. Diabet. Med. (1999) [Pubmed]
  6. Outcomes of patients with hypertension and non-insulin dependent diabetes mellitus treated by different systems and specialties. Results from the medical outcomes study. Greenfield, S., Rogers, W., Mangotich, M., Carney, M.F., Tarlov, A.R. JAMA (1995) [Pubmed]
  7. Effect of dalteparin on healing of chronic foot ulcers in diabetic patients with peripheral arterial occlusive disease: a prospective, randomized, double-blind, placebo-controlled study. Kalani, M., Apelqvist, J., Blombäck, M., Brismar, K., Eliasson, B., Eriksson, J.W., Fagrell, B., Hamsten, A., Torffvit, O., Jörneskog, G. Diabetes Care (2003) [Pubmed]
  8. Reducing dynamic foot pressures in high-risk diabetic subjects with foot ulcerations. A comparison of treatments. Lavery, L.A., Vela, S.A., Lavery, D.C., Quebedeaux, T.L. Diabetes Care (1996) [Pubmed]
  9. Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot. A pilot, randomized, double-blind, placebo-controlled study. Richard, J.L., Parer-Richard, C., Daures, J.P., Clouet, S., Vannereau, D., Bringer, J., Rodier, M., Jacob, C., Comte-Bardonnet, M. Diabetes Care (1995) [Pubmed]
  10. The effect of short-contact topical tretinoin therapy for foot ulcers in patients with diabetes. Tom, W.L., Peng, D.H., Allaei, A., Hsu, D., Hata, T.R. Archives of dermatology. (2005) [Pubmed]
  11. Antibiotic treatment for uncomplicated neuropathic forefoot ulcers in diabetes: a controlled trial. Chantelau, E., Tanudjaja, T., Altenhöfer, F., Ersanli, Z., Lacigova, S., Metzger, C. Diabet. Med. (1996) [Pubmed]
  12. Role of neuropathy and plasma nitric oxide in recurrent neuropathic and neuroischemic diabetic foot ulcers. Jude, E.B., Tentolouris, N., Appleton, I., Anderson, S., Boulton, A.J. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2001) [Pubmed]
  13. Hydroxyurea-induced foot ulcer successfully treated with a topical basic fibroblast growth factor product. Aragane, Y., Okamoto, T., Yajima, A., Isogai, R., Kawada, A., Tezuka, T. Br. J. Dermatol. (2003) [Pubmed]
  14. Fluorescein angiography for predicting healing of foot ulcers. Wallin, L., Björnsson, H., Stenström, A. Acta orthopaedica Scandinavica. (1989) [Pubmed]
  15. Randomized single-blind trial of topical ketanserin for healing acceleration of diabetic foot ulcers. Martínez-de Jesús, F.R., Morales-Guzmán, M., Castañeda, M., Pérez-Morales, A., García-Alonso, J., Mendiola-Segura, I. Arch. Med. Res. (1997) [Pubmed]
  16. Transcutaneous oxygen pressure as predictive parameter for ulcer healing in endstage vascular patients treated with spinal cord stimulation. Claeys, L.G., Horsch, S. International angiology : a journal of the International Union of Angiology. (1996) [Pubmed]
  17. Enzyme activities in skeletal muscles from patients with peripheral arterial insufficiency. Bylund, A.C., Hammarsten, J., Holm, J., Scherstén, T. Eur. J. Clin. Invest. (1976) [Pubmed]
  18. Saving the diabetic foot with special reference to the patient with chronic renal failure. Deery, H.G., Sangeorzan, J.A. Infect. Dis. Clin. North Am. (2001) [Pubmed]
  19. Premature aging syndrome with osteosarcoma, cataracts, diabetes mellitus, osteoporosis, erythroid macrocytosis, severe growth and developmental deficiency. Okamoto, N., Satomura, K., Hatsukawa, Y., Hayashida, M., Saijo, K., Ohno, T., Goto, M. Am. J. Med. Genet. (1997) [Pubmed]
  20. New treatments in ulcer healing and wound infection. Edmonds, M., Bates, M., Doxford, M., Gough, A., Foster, A. Diabetes Metab. Res. Rev. (2000) [Pubmed]
  21. Ketanserin in the treatment of diabetic foot ulcer with severe peripheral vascular disease. Apelqvist, J., Castenfors, J., Larsson, J., Stenström, A., Persson, G. International angiology : a journal of the International Union of Angiology. (1990) [Pubmed]
  22. Leukocytoclastic angiitis induced by clindamycin. Lambert, W.C., Kolber, L.R., Proper, S.A. Cutis; cutaneous medicine for the practitioner. (1982) [Pubmed]
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