High impact information on STRBP

• Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules [1].
• Immunolocalization of the Spnr protein within the testis shows that it is expressed exclusively in postmeiotic germ cells and that it is localized to the manchette, a spermatid-specific microtubular array [1].
• Spermatid perinuclear RNA-binding protein (SPNR) is a microtubule-associated RNA-binding protein that localizes to the manchette in developing spermatids [2].
• Our findings suggest that SPNR plays an important role in normal spermatogenesis and sperm function [2].
• Other DRBPs such as Staufen, adenosine deaminase acting on RNA (ADAR), and spermatid perinuclear RNA binding protein (SPNR) are known to play essential roles in development, translation, RNA editing, and stability [3].

Anatomical context of STRBP

• The Spnr mRNA is expressed at high levels in testis, ovary, and brain and is present in these tissues in multiple forms [2].
• SPNR could bind manchette microtubules directly, or it could bind indirectly via an interaction with a microtubule-associated protein (MAP) [4].

References