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Gene Review:

PRKAB2 - protein kinase, AMP-activated, beta 2 non...

Homo sapiens

Synonyms: 5'-AMP-activated protein kinase subunit beta-2, AMPK subunit beta-2

Prochazka, M. et al., McKay, S.D. et al.

Prochazka, Farook, Ossowski, Wolford, Bogardus,

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Disease relevance of PRKAB2

Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians [1].

High impact information on PRKAB2

PRKAB2 and PRKAG3, however, have not been mapped in humans [2].
We conclude that variants in PRKAB2 are unlikely to contribute to the disease susceptibility in Pima Indians [1].
We have investigated the PRKAB2 gene encoding the beta2 subunit, which is located on chromosome 1q within a region linked with type 2 diabetes mellitus (T2DM) in the Pima Indians and four different Caucasian populations [1].

References

Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians. Prochazka, M., Farook, V.S., Ossowski, V., Wolford, J.K., Bogardus, C. Mol. Cell. Probes (2002) [Pubmed]
The bovine 5' AMPK gene family: mapping and single nucleotide polymorphism detection. McKay, S.D., White, S.N., Kata, S.R., Loan, R., Womack, J.E. Mamm. Genome (2003) [Pubmed]

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AKINBETA1	Arabidopsis thaliana
PRKAB2	Bos taurus
aakb-1	Caenorhabditis elegans
aakb-2	Caenorhabditis elegans
PRKAB2	Canis lupus familiaris
prkab2	Danio rerio
PRKAB2	Gallus gallus
PRKAB2	Macaca mulatta
Prkab2	Mus musculus
Os05g0491200	Oryza sativa Japonica Group
PRKAB2	Pan troglodytes
Prkab2	Rattus norvegicus
SIP2	Saccharomyces cerevisiae S288c
prkab2	Xenopus (Silurana) tropicalis

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