Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

SMEK1 - SMEK homolog 1, suppressor of mek1...

Homo sapiens

Synonyms: FLFL1, FLJ20707, KIAA2010, MSTP033, PP4R3A, ...

Mendoza, M.C. et al.

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High impact information on SMEK1

These data suggest that loss of MEK1/ERK1 signaling compromises gene expression and chemotaxis in a SMEK-dependent manner [1].
Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects [1].

Biological context of SMEK1

Here, we describe a novel, evolutionarily conserved gene and protein (smkA and SMEK, respectively), whose loss partially suppresses the mek1(-) chemotaxis phenotypes [1].

References

Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects. Mendoza, M.C., Du, F., Iranfar, N., Tang, N., Ma, H., Loomis, W.F., Firtel, R.A. Mol. Cell. Biol. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AT3G06670	Arabidopsis thaliana
SMEK1	Bos taurus
smk-1	Caenorhabditis elegans
SMEK1	Canis lupus familiaris
smek1	Danio rerio
SMEK1	Gallus gallus
MGG_06138	Magnaporthe oryzae 70-15
Smek1	Mus musculus
NCU11315	Neurospora crassa OR74A
Os01g0337600	Oryza sativa Japonica Group
SMEK1	Pan troglodytes
Smek1	Rattus norvegicus
SPBC216.01c	Schizosaccharomyces pombe 972h-
LOC100485426	Xenopus (Silurana) tropicalis

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