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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LMBR1L  -  limb development membrane protein 1-like

Homo sapiens

Synonyms: FLJ10494, KIAA1174, LIMR, Limb region 1 protein homolog-like, Lipocalin-1-interacting membrane receptor, ...
 
 
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High impact information on LMBR1L

  • Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells [1].
  • Whereas control NT2 cells rapidly internalized (125)I-Lcn-1 or fluorescein isothiocyanate-labeled Lcn-1, NT2 cells that were made LIMR deficient by cDNA antisense expression greatly accumulated Lcn-1 in the culture medium but did not internalize it [1].
  • According to data derived from the human genome sequencing project, the LIMR-encoding gene has to be mapped on human chromosome 12, and its intron/exon organization could be established [2].
  • The entire LIMR-encoding gene consists of about 13.7 kilobases in length and contains 16 introns with a length between 91 and 3438 base pairs [2].
 

Analytical, diagnostic and therapeutic context of LMBR1L

References

  1. Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells. Wojnar, P., Lechner, M., Redl, B. J. Biol. Chem. (2003) [Pubmed]
  2. Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display. Wojnar, P., Lechner, M., Merschak, P., Redl, B. J. Biol. Chem. (2001) [Pubmed]
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